新生儿血清25(OH)D水平及其与钙、磷、碱性磷酸酶的关系分析  

An Analysis of Serum 25(OH)D Level and Its Relationship with Calcium, Phosphorus and Alkaline Phosphatase in Newborns

作　　者：王艳萍 李明[2] 孙明明 梁霞 张雯 

机构地区：[1]青岛市海慈医院,山东 青岛 [2]青岛市市立医院,山东 青岛 [3]青岛市城阳人民医院,山东 青岛 [4]河南中医药大学,河南 郑州

出　　处：《临床医学进展》2021年第6期2744-2752,共9页Advances in Clinical Medicine

摘　　要：目的:探讨不同胎龄不同出生体重新生儿血清25(OH)D、钙、磷、碱性磷酸酶(ALP)水平,并对新生儿体内25(OH)D与钙、磷、钙磷乘积及ALP进行相关性分析,形成对本地区新生儿骨代谢的初步认识。方法:1) 选择2016年4月~2017年5月本院新生儿病室收治的新生儿共158例,检测其出生后3天内血清25(OH)D、钙、磷、ALP水平,比较不同胎龄、不同出生体重新生儿之间25(OH)D、钙、磷、ALP的差异。2) 分别将25(OH)D与钙、磷、钙磷乘积、ALP进行相关性分析,明确钙、磷、ALP对新生儿体内25(OH)D的影响。结果:1) 按胎龄分组,28~【33周组的新生儿血清25(OH)D、血钙显著低于另外两组,血清25(OH)D缺乏率高达57.16%,明显高于另外两组,差异有统计学意义(P 【0.05);不同组别之间血磷、血碱性磷酸酶差别无统计学意义。2) 按出生体质量分组,VLBW组的血清25(OH)D、血钙、碱性磷酸酶显著低于其余三组,差异有统计学意义(P 【0.05);VLBW组新生儿血清25(OH)D缺乏率高达50%,明显高于其余三组,差异有统计学意义(P 【0.05)。3) 新生儿体内25(OH)D含量与血钙浓度呈线性正相关(r = 0.16, P = 0.04)、与碱性磷酸酶含量呈线性负相关(r = −0.25, P = 0.001),体内25(OH)D含量越高,体内血钙水平也越高;另一角度,新生儿体内25(OH)D含量越低,ALP的水平却越高。结论:1) 新生儿体内25(OH)D含量与胎龄及出生体质量有关,胎龄越小、出生体质量越低的新生儿25(OH)D含量越少,日后发生代谢性骨病的可能性越大;2) 青岛地区新生儿体内25(OH)D普遍不足,需尽早补充维生素D,预防代谢性骨病的发生;3) 新生儿体内25(OH)D含量与钙含量呈正相关,与ALP水平呈负相关。Objective: To study serum 25(OH)D, calcium, phosphorus and alkaline phosphatase (ALP) levels of newborns with different gestational age and birth weight, and, to analyze the correlation between 25(OH)D and calcium, phosphorus, calcium-phosphorus product and ALP in neonates. Methods: 1) We selected a total of 158 newborns hospitalized in the neonatal intensive care unit of our hospital from April 2016 to May 2017, and, measured serum levels of 25(OH)D, calcium, phosphorus and ALP in these newborns within 3 days after birth. We compared the differences of 25(OH)D, calcium, phosphorus and ALP among neonates of different gestational ages and birth weights. 2) We analyzed the correlation between 25(OH)D and calcium, phosphorus, calcium phosphorus product and ALP, and, found the relationship between 25(OH)D and calcium, phosphorus and ALP in neonates. Results: 1) According to the group of gestational age, serum 25(OH)D and serum calcium of newborns in the group of 28~<33 weeks were significantly lower than the other two groups, and the serum 25(OH)D deficiency rate was as high as 57.16%, significantly higher than the other two groups, with statistically significant differences (P <0.05). There was no significant difference in blood phosphorus and alkaline phosphatase between different groups. 2) According to the group of birth weight, serum 25(OH)D, serum calcium and alkaline phosphatase in the very low birth weight group were significantly lower than those in the other three groups, with statistically significant differences (P <0.05). The serum 25(OH)D deficiency rate of newborns in the very low birth weight group was as high as 50%, which was significantly higher than the other three groups, and the difference was statistically significant (P <0.05). 3) There was a positive linear correlation between the content of 25(OH)D in neonates and serum calcium concentration (r = 0.16, P = 0.04) and the content of alkaline phosphatase (r = −0.25, P = 0.001). On the other hand, the lower the level of 25(OH)D, th

关 键 词：血清25(OH)D 新生儿 代谢性骨病 

分 类 号：R72[医药卫生—儿科]