自噬在香烟烟雾诱导的慢性阻塞性肺疾病中的作用及研究进展  

The Role and Research Progress of Autophagy in Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke

作　　者：张欣月 张骞 李江娅 梁丽菊 翁稚颖 

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室,云南 昆明

出　　处：《临床医学进展》2022年第2期886-891,共6页Advances in Clinical Medicine

摘　　要：香烟烟雾中含有多种有害物质,其诱导的炎症反应是引发COPD的重要因素。自噬是一种细胞维持自身内环境稳态的重要机制,即将受损细胞器或大分子物质吞噬并降解的过程。自噬在香烟烟雾诱导的COPD发生与发展中起到重要的作用,它涉及炎症反应、氧化应激与细胞凋亡等多种生理过程。因此本文以自噬在香烟烟雾诱导的慢性阻塞性肺疾病中的作用及作用机制进行综述。Cigarette smoke contains a variety of harmful substances, and its induced inflammatory response is an important factor in COPD. Autophagy is an important mechanism for cells to maintain homeostasis in their internal environment, that is, the process of phagocytosis and degradation of damaged organelles or macromolecules. Autophagy plays an important role in the occurrence and development of COPD induced by cigarette smoke, which involves a variety of physiological processes such as inflammatory response, oxidative stress and apoptosis. Therefore, this paper reviews the role and mechanism of autophagy in chronic obstructive pulmonary disease induced by cigarette smoke.

关 键 词：自噬 香烟烟雾 慢性阻塞性肺疾病 炎症反应 

分 类 号：R563[医药卫生—呼吸系统]