早产儿应用多种油脂肪乳的非特异性炎症、肝功、凝血功能指标分析  

Analysis of Non-Specific Inflammation, Liver Function, and Coagulation Function Indexes of Premature Infants Using Various Oil and Fat Emulsions

作　　者：顾兆丹 王永芹[2] 刘茜[2] 张潇[2] 桑玉童 杜玥瑾 

机构地区：[1]潍坊医学院,山东 潍坊 [2]潍坊医学院附属医院儿科,山东 潍坊

出　　处：《临床医学进展》2022年第3期1776-1782,共7页Advances in Clinical Medicine

摘　　要：目的:比较早产儿应用多种油脂肪乳(SMOF)与中长链脂肪乳(MCT/LCT)的非特异性炎症、肝功、凝血功能指标,以指导临床应用。方法:回顾性纳入2020年1月1日至2021年9月30日收治的41例早产儿为研究对象,入院时日龄 ≤ 24 h,接受胃肠外营养时间 ≥ 10 d。根据应用的脂肪乳剂种类,分为SMOF组(n = 20)和MCT/LCT组(n = 21),比较两组患儿间非特异性炎症指标、肝功、凝血功能指标变化。结果:非特异性炎症指标比较,SMOF组的WBC数值下降较MCT/LCT组明显,差异具有统计学意义;肝功能指标比较,SMOF组TBIL数值上升较MCT/LCT组幅度小,差异具有统计学意义;凝血功能指标比较,SMOF组与MCT/LCT组的PT数值存在差异,差异具有统计学意义。结论:SMOF应用于早产儿,具有抗炎、保护肝功能的优势,且对凝血功能影响不大,安全性更高,值得使用推广。Objective: To compare the non-specific inflammation, liver function and coagulation function indexes of SMOF and MCT/LCT in preterm infants to guide clinical application. Methods: The 41 premature infants admitted from January 1, 2020 to September 30, 2021 were retrospectively included as the research objects. The age at admission was ≤ 24 h and the duration of parenteral nutririon was ≥ 10 d. According to the types of fat emulsion received, the preterm infants were divided into two groups: SMOF group (n = 20) and MCT/LCT group (n = 21). Compare the indicator changes of non-specific inflammation indexes, liver function, and coagulation function between the two groups. Results: In the comparison of non-specific inflammation indexes, the WBC value of the SMOF group decreased significantly than that of the MCT/LCT group, and the difference was statistically significant;in the comparison of liver function indexes, the TBIL value of the SMOF group decreased significantly than that of the MCT/LCT group, and the difference was statistically significant. In the comparison of coagulation function indexes, the PT values of SMOF group and MCT/LCT group are different, and the difference is statistically significant. Conclusion: The use of SMOF in premature infants has the advantages of anti-inflammatory and protecting liver function, and has little effect on blood coagulation function, so it has higher safety. It is worthy of promotion.

关 键 词：早产儿 脂肪乳剂 肠外营养 非特异性炎症指标 肝功 凝血功能 

分 类 号：R722.6[医药卫生—儿科]