儿童EB病毒原发性感染相关疾病研究进展  

Related Research Progress of Epstein-Barr Virus Associated Diseases with Primary Infection in Children

作　　者：刘茂艳 詹学[1] 

机构地区：[1]重庆医科大学附属儿童医院消化科,国家儿童健康与疾病临床医学研究中心,儿童发育疾病研究教育部重点实验室,儿科学重庆市重点实验室,重庆

出　　处：《临床医学进展》2022年第3期2211-2217,共7页Advances in Clinical Medicine

摘　　要：EB病毒(Epstein-Barr virus, EBV)属嗜人类B淋巴细胞的DNA病毒,儿童普遍易感。一旦感染后可在人体B淋巴细胞建立潜伏性感染,终生携带病毒。在免疫力低下者体内通过多种途径导致复杂疾病,如传染性单核细胞增多症、噬血细胞性淋巴组织细胞增生症、淋巴瘤等。对儿童EB病毒原发性感染相关性疾病的研究具有重要临床意义,帮助实现患儿的早期诊治、合理治疗,避免延误病情。Epstein-Barr (EB) virus is a kind of DNA virus that belongs to human B lymphocytophilic DNA virus. Children are generally susceptible. Once infected, it could establish latent infection in human B lymphocytes, carrying the virus for life. In patients with impaired immunity, EBV infection could lead to complex and potentially refractory diseases, such as infectious mononucleosis, hemophagocytic lymphohistiocytosis and lymphoma. It is of great clinical significance to study the diseases related to primary Epstein-Barr virus infection in children, which can help realize early diagnosis and treatment of children and avoid delaying their illness.

关 键 词：EB病毒 慢性活动性EBV感染 EBV相关性噬血细胞性淋巴组织细胞增生症 弥漫大B细胞淋巴瘤 伯基特淋巴瘤 

分 类 号：R725.1[医药卫生—儿科]