铁代谢在心血管疾病中的研究  

Study on Iron Metabolism in Cardiovascular Diseases

作　　者：张敏[1] 苏晓灵[1] 

机构地区：[1]青海大学,青海 西宁

出　　处：《临床医学进展》2022年第3期2417-2423,共7页Advances in Clinical Medicine

摘　　要：铁是一种体内微量金属,也是几乎所有活细胞和生物体的基本成分。作为各种金属蛋白的组成部分,它参与了关键的生化过程,如组织中氧的运输、线粒体呼吸过程中的电子转移反应、DNA的合成和修复、外源性物质的代谢等。然而,当细胞和组织中存在过量时,铁会破坏氧化还原稳态,并催化活性氧(reactive oxygen species, ROS)的传播,导致氧化应激。ROS对生理信号通路至关重要,但氧化应激与组织损伤和疾病有关。在细胞水平上,氧化应激可能导致铁死亡,一种依赖铁的细胞死亡形式。目前很多相关研究已经证实铁代谢异常所导致的氧化应激与心血管疾病的发病是明确相关的。在这篇综述中,我们着重于讨论铁代谢异常及氧化应激和心血管疾病之间的关系。Iron is a kind of trace metal in the body, and is also the basic component of almost all living cells and organisms. As a component of various metalloproteins, it is involved in key biochemical processes, such as oxygen transport in tissues, electron transfer reactions during mitochondrial respiration, DNA synthesis and repair, and metabolism of exogenous substances. However, when excess is present in cells and tissues, iron disrupts REDOX homeostasis and catalyzes the spread of reactive oxygen species (ROS), leading to oxidative stress. ROS is critical to physiological signaling pathways, but oxidative stress has been linked to tissue damage and disease. At the cellular level, oxidative stress may cause iron death, an iron-dependent form of cell death. At present, many relevant studies have confirmed that oxidative stress caused by abnormal iron metabolism is clearly related to the incidence of cardiovascular diseases. In this review, we focus on the relationship between abnormal iron metabolism and oxidative stress and cardiovascular disease.

关 键 词：铁代谢 铁死亡 氧化应激 心血管疾病 活性氧 

分 类 号：R543[医药卫生—心血管疾病]