人脐带间充质干细胞来源的外泌体在皮肤老化方面的作用  

Role of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells in Skin Aging

作　　者：石星星 杨喜明[2] 

机构地区：[1]延安大学,陕西 延安 [2]延安大学附属医院医学美容科,陕西 延安

出　　处：《临床医学进展》2022年第4期3457-3462,共6页Advances in Clinical Medicine

摘　　要：干细胞治疗是修复衰老受损组织、恢复皮肤弹性活力的一种安全、实用、有效的治疗来源。先前的实验证明,间充质干细胞来源的外泌体对皮肤衰老有治疗作用,在一定程度上为管理皮肤和面部皮肤老化提供了一种有前途和有效的替代方案,但近年来发现人脐带间充质干细胞源性外泌体(Human umbilicai cord mesenchymal stem cells-exosome, HUCMSCs-ex)在缓解皮肤衰老方面表现出巨大的治疗潜力,这也成为医学美容领域研究的热点问题。本文现就人脐带间充质干细胞来源的外泌体功能特性及其在治疗皮肤老化中的研究机制方面作一综述,提出目前所面临的临床问题,并对其未来的临床应用进行了展望。Stem cell therapy is a safe, practical and effective treatment source for repairing aging damaged tissues and restoring skin elasticity. Previous experiments have demonstrated that exosomes derived from mesenchymal stem cells have therapeutic effects on skin aging, providing a promising and effective alternative for managing skin and facial skin aging to a certain extent. However, in recent years, human umbilicai cord mesenchymal stem cells-exosome (HUCMSCs-ex) has been found to show great therapeutic potential in alleviating skin aging, which has become a hot topic in the field of medical cosmetology research. In this review, the functional characteristics of exosomes derived from human umbilical cord mesenchymal stem cells and their mechanisms in the treatment of skin aging are reviewed, the current clinical problems are put forward, and the future clinical applications of exosomes are prospected.

关 键 词：人脐带间充质干细胞 外泌体 人脐带间充质干细胞来源的外泌体 面部年轻化 皮肤衰老 

分 类 号：R751[医药卫生—皮肤病学与性病学]