哮喘患者气道上皮屏障功能受损的机制  

Mechanism of Impaired Airway Epithelial Barrier Function in Patients with Asthma

作　　者：吴梦 李敏超[2] 

机构地区：[1]重庆医科大学,重庆 [2]重庆医科大学附属第二医院,重庆

出　　处：《临床医学进展》2022年第4期3257-3264,共8页Advances in Clinical Medicine

摘　　要：支气管哮喘是一类异质性疾病,发病机制主要与气道免疫–炎症、气道高反应性、气道重塑等相关。其中气道上皮屏障是呼吸道抵御外界有害物质的首要防线,发挥着化学、物理及免疫屏障的功能,是病理改变的主要部位之一。近年来已有许多研究发现哮喘患者的气道上皮屏障均受到不同程度的损害。气道上皮屏障的损伤与变应原、呼吸道感染、环境污染等因素息息相关,其中各种细胞因子、模式受体、信号通路参与其中。本篇综述主要介绍了气道上皮屏障的结构和分子组成,探讨上皮屏障功能障碍在哮喘发病机制中的作用以及简单介绍目前改善气道上皮屏障的一些治疗方法。Bronchial asthma is a heterogeneous disease, and its pathogenesis is mainly related to airway immune-inflammation, airway hyperresponsiveness and airway remodeling. Among them, airway epithelial barrier is the primary defense of respiratory tract against external harmful substances, plays the function of chemical, physical and immune barrier, and is one of the main parts of pathological changes. In recent years, many studies have found that the airway epithelial barrier in patients with asthma is damaged to varying degrees. The damage of airway epithelial barrier is closely related to allergen, respiratory tract infection and environmental pollution, among which various cytokines, model receptors and signaling pathways are involved. This review mainly in-troduces the structure and molecular composition of airway epithelial barrier, discusses the role of epithelial barrier dysfunction in the pathogenesis of asthma, and briefly introduces some current treatments for improving airway epithelial barrier.

关 键 词：哮喘 气道上皮细胞 屏障功能 损伤机制 

分 类 号：R562.25[医药卫生—呼吸系统]