静脉血栓栓塞症的原发性及继发性危险因素分析  

Analysis of the Primary and Secondary Risk Factors of Venous Thromboembolism

作　　者：许风雷[1] 胡军[2] 孜莱克 周琴[2] 菅辉玲[2] 张益枝[2] 高丽霞[2] 

机构地区：[1]新疆克拉玛依市中心医院神经内科,新疆 克拉玛依 [2]新疆克拉玛依市中心医院血液肿瘤科,新疆 克拉玛依

出　　处：《临床医学进展》2022年第5期4877-4884,共8页Advances in Clinical Medicine

摘　　要：目的:通过分析108例静脉血栓栓塞症(VTE)患者的临床资料,检查患者蛋白C (PC)、蛋白S (PS)、抗凝血酶III (ATIII)活性水平,探讨原发性和继发性危险因素与静脉血栓栓塞症的关系,为VTE的及早预防提供理论依据。方法:收集克拉玛依市中心医院108例VTE病例组(2014年1月至2019年1月收治的VTE)及52例对照组患者的临床资料,检测PC、PS、ATIII活性等指标,分析抗凝蛋白缺陷与VTE的关系,及患者年龄、性别、临床特征及继发性危险因素。结果:VTE患者的PC、PS、ATIII活性结果与对照组比较明显降低,差异有统计学意义(P 2 = 25.46, P 2 = 5.733, P 肺癌 】妇科肿瘤 】泌尿系肿瘤 】乳腺癌)。恶性肿瘤合并VTE患者的比例最高。结论:蛋白C (Protein C, PC)、蛋白S (Protein S, PS)和抗凝血酶III (Antithrombin III, ATIII)缺陷是促发VTE发生的重要原发性危险因素,以PS、PC缺陷为主,抗凝蛋白缺陷可能是血栓复发的重要危险因素。继发性危险因素以外伤/手术和恶性肿瘤为主。多种因素并存是引起VTE的重要原因。Objective: By analyzing the clinical data of 108 patients with VTE, the activity levels of protein C (PC), protein S (PS), antithrombin III (ATIII) were examined, and the relationship between the primary and secondary risk factors and VTE was discussed to provide theoretical basis for the early preven-tion of VTE. Method: The clinical data of 108 cases of VTE (VTE admitted from January 2014 to Janu-ary 2019) and clinical data of 52 patients in the control group were collected to detect the activity of PC, PS and ATIII, analyze the relationship between anticoagulant protein deficiency and VTE, and the age, gender, clinical characteristics and secondary risk factors of patients. Results: The activity of PC, PS and ATIII in VTE patients was significantly lower than that in the control group (P 2 = 25.46, P 2 = 5.733, P <0.05). The top two secondary risk factors were trauma/surgery (Department of orthopedics operation), malignant tumor. The proportion of patients with VTE is the highest. Conclusion: The defects of PS, PC and at ATIII are the important primary risk factors for VTE. The defect of anticoagulant protein may be the important risk factors for thrombosis recurrence. The main secondary risk factors were trauma/operation and malignant tumor. The coexistence of many factors is an important cause of VTE.

关 键 词：静脉血栓栓塞症 蛋白C蛋白S 抗凝血酶III 继发性危险因素 

分 类 号：R563.5[医药卫生—呼吸系统]