新生儿水痘的临床特征  

The Clinical Feature of Neonatal Varicella

作　　者：朱静[1] 

机构地区：[1]重庆医科大学附属儿童医院感染科,儿童发育疾病研究教育部重点实验室,国家儿童健康与疾病临床医学研究中心,儿童发育重大疾病国家国际科技合作基地,儿童感染免疫重庆市重点实验室,重庆

出　　处：《临床医学进展》2022年第5期4903-4908,共6页Advances in Clinical Medicine

摘　　要：目的:探讨新生儿水痘的临床特征。方法:回顾分析2011年1月至2021年6月收治的68例新生儿水痘的临床资料。结果:68例患儿中通过垂直传播被感染54例(79.4%),仅4例无明确水痘患者接触史,1月及12月为发病高峰。所有患儿均有典型皮疹,伴随发热症状45例(66.2%),并发皮肤细菌感染者46例(67.6%),并发肺炎者43例(63.2%),并发脑炎者7例(63.2%),并发肝炎者6例(8.8%),无并发症者4例(5.9%),重症水痘7例(10.3%)。60例接受静脉注射用免疫球蛋白治疗,29例接受静脉阿昔洛韦治疗,并发细菌感染予以抗生素治疗,最终死亡3例(4.4%)。结论:新生儿水痘临床表现典型,并发症多,有较高的病死率,应积极治疗,重在预防。Objective: To explore the clinical feature of neonatal varicella. Methods: The clinical data of 68 neo-nates with varicella admitted from January 2011 to June 2021 were retrospectively analyzed. Re-sults: Among 68 cases, 54 cases (79.4%) were infected through vertical transmission, and only 4 cases had no clear history of exposure to varicella, and the peak incidence was in January and De-cember. All of the cases had the typical skin rashes, including 45 cases (66.2%) with fever, 46 cases (67.6%) with bacterial infection, 43 cases (63.2%) with pneumonia, 7 cases (63.2%) with encepha-litis, 6 cases (8.8%) with hepatitis, 4 cases (5.9%) without complications, and 7 cases (10.3%) with severe varicella. 60 patients were treated with intravenous immunoglobulin, 29 cases with intra-venous acyclovir, and antibiotics for bacterial infection, resulting in 3 deaths (4.4%). Conclusions: The clinical manifestations of neonatal varicella are typical, with many complications and a high mortality rate. It should be actively treated, focusing on prevention.

关 键 词：新生儿 水痘 临床特征 

分 类 号：R722.1[医药卫生—儿科]