趋化因子和共刺激分子在儿童肺炎支原体肺炎发病机制中的研究进展  

Research Progress of Chemokine and Costimulatory Molecules in the Pathogenesis of Mycoplasma pneumoniae Pneumonia in Children

作　　者：辛春玲 吴秀萍[2] 

机构地区：[1]青海大学研究生院,青海 西宁 [2]青海大学附属医院儿科,青海 西宁

出　　处：《临床医学进展》2022年第6期5937-5945,共9页Advances in Clinical Medicine

摘　　要：近年来由于肺炎支原体肺炎在临床上发病率持续升高,且具有病情变化多、进展快、严重者可导致多个系统损害等特点,是临床诊治中需要面对的难题,因此对于早期识别及评估MPP严重程度尤为重要。越来越多的研究证明趋化因子、共刺激分子等炎症性因子在肺炎支原体肺炎中发挥重要作用。趋化因子参与多种急慢性肺部炎性疾病;共刺激分子参与机体免疫反应,进而造成自身免疫性损伤。本文将趋化因子和共刺激分子在儿童肺炎支原体肺炎发病机制中的研究进展作如下综述。In recent years, as the clinical incidence rate of Mycoplasma pneumoniae pneumonia continues to rise, and it has the characteristics of many changes, rapid progress, and serious cases can lead to multiple system damage, which is a difficult problem in clinical diagnosis and treatment, so it is particularly important to identify and evaluate the severity of MPP in the early stage. More and more studies have proved that inflammatory factors such as chemokines and costimulatory mole-cules play an important role in Mycoplasma pneumoniae pneumonia. Chemokines are involved in many acute and chronic pulmonary inflammatory diseases. Costimulatory molecules participate in the body’s immune response, and then cause autoimmune injury. This paper reviews the research progress of chemokines and costimulatory molecules in the pathogenesis of Mycoplasma pneu-moniae pneumonia in children as follows.

关 键 词：肺炎支原体肺炎 机体免疫反应 共刺激分子 趋化因子 病情变化 早期识别 系统损害 发病机制 

分 类 号：R725.6[医药卫生—儿科]