血小板计数、大血小板比率、血小板分布宽度在急性肺栓塞诊断中的临床价值  

Clinical Value of Platelets Count, Platelet-Larger Cell Ratio and Platelet Distribution Width in the Diagnosis of Acute Pulmonary Embolism

作　　者：许小艳 李桂琼[2] 

机构地区：[1]重庆三峡医药高等专科学校附属人民医院,重庆 [2]重庆医科大学附属第二医院,重庆

出　　处：《临床医学进展》2022年第9期8686-8694,共9页Advances in Clinical Medicine

摘　　要：研究背景:肺栓塞(Pulmonary embolism, PE)是一种常见的肺血管疾病,但肺栓塞的诊断率低、死亡率高,临床上需要寻找其他更多指标对该病的诊断及治疗起指导作用。血小板是血栓形成过程中不可或缺的因素,血小板相关参数在多种血栓性疾病中的变化情况越来越受到关注。目的:分析血小板计数(Platelet count, PLT)、大血小板比率(Platelet-larger cell ratio, P-LCR)、血小板分布宽度(Platelet distribution width, PDW)在急性肺栓塞(Acute pulmonary embolism, APE)患者诊断及危险分层中的预测价值。方法:回顾性分析2019年1月~2021年12月重庆医科大学附属第二医院收治的APE患者(APE组) 88例临床资料,同时选取相同时间段的健康体检者88例作为对照组。比较2组之间及不同危险分层之间PLT、P-LCR、PDW有无显著差异;分析PLT、P-LCR、PDW对APE诊断的预测价值。结果:APE组PLT低于对照组(P = 0.011),APE组P-LCR高于对照组(P 0.05)。结论:PLT在急性肺栓塞患者中降低,P-LCR、PDW在急性肺栓塞患者中升高,对APE诊断有一定预测价值及指导作用,但对肺栓塞危险分层无指导作用。Background: Pulmonary embolism is a common pulmonary vascular disease, but due to the low di-agnosis rate and high mortality rate, more indicators are still needed to guide the diagnosis and treatment in clinic. Platelet is an indispensable factor in the process of thrombosis. At present, many scholars pay attention to the changes of platelet-related parameters in thrombotic diseases. Objective: To analyze the predictive value of platelet count (PLT), platelet-larger cell ratio (P-LCR) and platelet distribution width (PDW) in the diagnosis of acute pulmonary embolism (APE) and risk stratification. Method: A retrospective analysis of the data of 88 patients in the APE group admitted to the Second Affiliated Hospital of Chongqing Medical University from January 2019 to December 2021, and 88 cases of healthy physical examination patients at the same period were selected as the control group. Compare the PLT, P-LCR, PDW level of the two groups and different risk layers, to analyze the predictive value of PLT, P-LCR and PDW for APE diagnosis. Results: PLT in APE group was lower than that in control group (P = 0.011), P-LCR in APE group was higher than that in control group (P 0.05). Conclusion: PLT decreased in patients with acute pulmonary embolism, while P-LCR and PDW increased, which has certain predictive value and guiding role in the diagnosis of APE, but it has no guiding effect on risk stratification of pulmonary embolism.

关 键 词：肺栓塞 血小板计数 大血小板比率 血小板分布宽度 血小板活化 

分 类 号：R563.5[医药卫生—呼吸系统]