阻塞性睡眠呼吸暂停患者日间过度嗜睡相关研究进展  

Research Progress on Excessive Daytime Sleepiness in Patients with Obstructive Sleep Apnea

作　　者：孙雨浩 李钦[2] 

机构地区：[1]潍坊医学院临床医学院,山东 潍坊 [2]临沂市人民医院,山东 临沂

出　　处：《临床医学进展》2022年第9期8726-8732,共7页Advances in Clinical Medicine

摘　　要：许多阻塞性睡眠呼吸暂停(Obstructive Sleep Apnea, OSA)患者都会出现日间过度嗜睡(Excessive daytime sleepiness, EDS),这种症状会对其日常活动、行为能力、认知、情绪和其他方面的健康造成一系列负面影响。虽然OSA的初级治疗,如持续气道正压通气(CPAP)治疗可以减少EDS的发生,但仍有相当一部分OSA患者在接受了临床治疗后仍继续经历EDS。目前OSA患者EDS的发生机制尚未完全明了,文献报道与以下因素有关:睡眠片断化、夜间低氧血症、细胞因子(IL-6和TNF-α)、肥胖、代谢异常(如糖尿病、胰岛素抵抗)、老龄化、抑郁及高碳酸血症等。本文就OSA患者EDS相关流行病学特征、评估方法、危险因素等内容作一综述。Many patients with Obstructive Sleep Apnea (OSA) experience excessive daytime sleepiness (EDS), which can have a range of negative effects on their daily activities, behavioral ability, cognition, mood, and other aspects of health. Although primary treatment for OSA, such as continuous positive airway pressure (CPAP) therapy, can reduce the occurrence of EDS, a significant number of OSA pa-tients continue to experience EDS after receiving clinical treatment. At present, the mechanism of EDS in OSA patients is not yet fully understood, and it is reported in the literature that it is related to the following factors: sleep fragmentation, nocturnal hypoxemia, cytokines (IL-6 and TNF-α), obe-sity, metabolic abnormalities (such as diabetes, insulin resistance), aging, depression and hyper-capnia. This article reviews the epidemiological characteristics, assessment methods, and related risk factors associated with EDS in OSA patients.

关 键 词：阻塞性睡眠呼吸暂停 日间过度嗜睡 综述 

分 类 号：R766[医药卫生—耳鼻咽喉科] R749.4[医药卫生—临床医学]