卵泡液葡萄糖代谢组学与卵母细胞发育潜能的研究进展  

Research Progress of Follicular FluidGlucose Metabolomics and Oocyte Development Potential

作　　者：刘小磊 熊正方[2] 

机构地区：[1]青海大学研究生院,青海 西宁 [2]青海省人民医院,青海 西宁

出　　处：《临床医学进展》2022年第10期8924-8927,共4页Advances in Clinical Medicine

摘　　要：卵泡液构成了卵母细胞生长发育的微环境,一定程度影响并决定了卵母细胞的发育与成熟。卵泡液代谢组学分为靶向和非靶向分析技术,如今通常利用色谱–质谱技术检测卵泡液中的代谢物。葡萄糖在卵泡液中的含量相对丰富,通过检测卵泡液中的葡萄糖含量、种类及代谢通路,能够预测卵母细胞的质量和发育潜能。本文现就卵泡液葡萄糖代谢组学预测卵母细胞发育潜能的研究进展作一综述。Follicle fluid constitutes the microenvironment of oocyte growth and development, which affects and determines the development and maturation of oocytes to some extent. Follicular metabolom-ics is divided into targeted and non-targeted analysis techniques. Nowadays, the metabolites in fol-licular fluid are usually detected by chromatography-mass spectrometry. The content of glucose in follicular fluid is relatively abundant. By detecting the content, type and metabolic pathway of glu-cose in follicular fluid, the quality and developmental potential of oocytes can be predicted. In this paper, the research progress of follicular fluid glucose metabolomics in predicting oocyte develop-ment potential is reviewed.

关 键 词：卵泡液 葡萄糖代谢组学 卵母细胞 发育潜能 

分 类 号：R714.8[医药卫生—妇产科学]