地氟烷对围术期心肌保护作用的研究进展  

Research Progress of Desflurane on Perioperative Myocardial Protection

作　　者：智嘉浩 盛明薇[2] 贾莉莉[2] 翁亦齐[2] 喻文立[2] 

机构地区：[1]天津医科大学一中心临床学院,天津 [2]天津市第一中心医院麻醉科,天津

出　　处：《临床医学进展》2022年第10期9070-9080,共11页Advances in Clinical Medicine

摘　　要：地氟烷是一种挥发性麻醉药,其心脏保护机制与线粒体及抗凋亡信号通路有关。动物实验和人体研究已经证明,在心脏手术中使用它们可以降低发病率和死亡率,包括减少心肌梗死面积和机械通气时间。一些研究通过减少心肌损伤生化标记物的释放表明其具有保护心肌功能的作用,同时,可以降低心血管术后并发症和死亡率,对术后转归也有一定帮助。本文总结了地氟烷参与心肌保护的可能机制以及对临床结果的观察归纳总结。Desflurane is a volatile anesthetic, and its cardioprotective mechanism is related to mitochondria and anti-apoptotic signaling pathway. Animal experiments and human studies have demonstrated that their use in cardiac surgery reduces morbidity and mortality, including a reduction in myocar-dial infarct size and mechanical ventilation time. Some studies have shown that it has a protective effect on myocardial function by reducing the release of biochemical markers of myocardial injury. At the same time, it can reduce the complications and mortality after cardiovascular surgery, and it is also helpful for the postoperative outcome. This article summarizes the possible mechanism of desflurane in myocardial protection and the observation and summary of clinical results.

关 键 词：地氟烷 挥发性麻醉药 心肌保护 心肌损伤 

分 类 号：R541[医药卫生—心血管疾病]