泡型棘球蚴感染中的DCs与IDO作用的研究进展  

Research Progress on the Interaction between DCs and IDO in Alveolar Echinococcosis Infection

作　　者：别文海 王宏宾[2] 孟茹 王雯 师正合 曹杰 

机构地区：[1]青海大学研究生院,青海 西宁 [2]青海大学附属医院,肝胆胰外科,青海 西宁 [3]青海省西宁兽医畜牧站,青海 西宁

出　　处：《临床医学进展》2022年第11期10678-10685,共8页Advances in Clinical Medicine

摘　　要：当机体感染棘球蚴病时,其所发生的免疫耐受反应主要由集体的树突状细胞介导,它是机体内一种抗原提呈细胞,它对于机体的免疫耐受及免疫应答反应有着至关重要的作用,在机体固有免疫中发挥关键作用。而当机体处于异常状态时,机体的DCs表面抗原可高表达吲哚胺2,3-过氧化酶(indoleamine-2,3 dioxygenase, IDO),其作为唯一可以催化色氨酸沿着犬鸟氨酸途径分解代谢的酶,直接对相应的靶器官产生免疫作用,并且在相关方面的免疫作用已有研究证实。因此本文旨在探究阐明调节DC诱导和维持IDO的机制,这可能会为新的临床干预措施的发展提供新思路,从不同层面来进行探究,以期发现其中的联系,对棘球蚴病新型疫苗的研发提供一定的理论依据。When the body is infected with echinococcosis, the immune tolerance is mainly mediated by den-dritic cells, DCs, which is a kind of antigen presenting cells, APC, which plays an important role in immune tolerance and immune response, and plays a key role in innate immunity. The DCs surface antigen of the body can highly express indoleamine 2-dioxygenase (indoleamine indoleam-ine-2-dioxygenase-3-dioxygenase). As the only enzyme that can catalyze the catabolism of trypto-phan along the canine ornithine pathway, it directly produces immunity to the corresponding tar-get organs, and the immune effect in tumor, inflammation, transplantation and so on has been con-firmed. Therefore, the purpose of this paper is to explore and clarify the mechanism of regulating the induction and maintenance of IDO by DC, which may provide new ideas for the development of new clinical interventions from different levels, in order to find the relationship between them, and provide a theoretical basis for the research and development of new vaccines for echinococcosis.

关 键 词：棘球蚴病 树突状细胞 吲哚胺2 3-过氧化酶 免疫耐受 免疫逃逸 

分 类 号：S85[农业科学—兽医学]