长链非编码RNA在系统性红斑狼疮发病机制中的研究进展  

Research Progress of Long Non-Coding RNA in the Pathogenesis of Systemic Lupus Erythematosus

作　　者：孟丽君 宋芹[2] 

机构地区：[1]济宁医学院临床医学院,山东 济宁 [2]济宁医学院附属医院,山东 济宁

出　　处：《临床医学进展》2022年第12期10947-10953,共7页Advances in Clinical Medicine

摘　　要：系统性红斑狼疮(systemic lupus erythematosus, SLE)是临床上常见的自身免疫性疾病,对人类生命健康造成极大破坏,所以及早发现、诊断和干预是当今防治的重要目标之一。关于系统性红斑狼疮的病因与发病机制目前仍尚未阐明,随着研究的不断推进,发现长链非编码RNA (lncRNA)在表观遗传、转录后基因调控等方面发挥重要作用,与疾病产生密切相关。本文就lncRNA在系统性红斑狼疮发病机制中的研究进展进行综述。Systemic lupus erythematosus (SLE) is a clinically common autoimmune disease that has a devas-tating impact on human life and health, so early detection, diagnosis, and intervention is one of the primary goals of prevention and treatment today. The etiology and pathogenesis of SLE are still unknown. Long non-coding RNA (lncRNA) has been discovered to play an important role in epige-netic and post-transcriptional gene regulation, as well as being closely associated with human dis-ease production. The progress of lncRNA research in the pathogenesis of systemic lupus erythema-tosus is reviewed in this paper.

关 键 词：系统性红斑狼疮 长链非编码RNA 标志物 治疗靶点 

分 类 号：R593.241[医药卫生—内科学]