3D生物打印骨组织工程支架在骨缺损修复中的研究进展  

Research Progress of 3D Biological Printing Bone Tissue Engineering Scaffolds in Bone Defect Repair

作　　者：郑中忍 王国栋[2] 马辉 赵晓伟[2] 

机构地区：[1]济宁医学院临床医学院,山东 济宁 [2]济宁医学院附属医院骨关节科,山东 济宁

出　　处：《临床医学进展》2022年第12期11823-11830,共8页Advances in Clinical Medicine

摘　　要：大面积骨缺损的再生修复一直是临床上亟待解决的问题,骨移植所带来的并发症问题,严重地限制了目前的治疗选择。因此寻找比骨移植更适宜的替代疗法已成为目前的研究热点。3D生物打印骨组织工程支架的出现为骨缺损的修复提供了新思路、新方向。通过采用不同材料获得具有良好机械性能和生物相容性的支架,促进骨骼和软组织的修补及诱导再生,进而满足骨缺损修复的复杂需求。本文就3D生物打印技术以及不同种类的3D生物打印支架在骨缺损修复中的发展状况进行总结阐述,并讨论了当前面临的挑战及未来发展的前景。The regeneration and repair of large bone defects has always been an urgent problem to be solved in clinical practice. The complications caused by bone transplantation seriously limit the current treatment options. Therefore, to find a more suitable alternative therapy than bone transplantation has become a research hotspot. The appearance of 3D biological printing bone tissue engineering scaffold provides a new idea and direction for bone defect repair. By using different materials to obtain scaffolds with good mechanical properties and biocompatibility, it can promote the repair and induced regeneration of bone and soft tissue, thus meeting the complex needs of bone defect repair. This paper summarized the development of 3D biological printing technology and different kinds of 3D biological printing scaffolds in bone defect repair, and discussed the current challenges and future development prospects.

关 键 词：3D生物打印 骨组织工程 仿生支架 骨缺损 

分 类 号：R318.08[医药卫生—生物医学工程] R687.3[医药卫生—基础医学]