CHA2DS2-Vasc评分联合血清FAR在冠心病中的诊断价值  

Diagnostic Value of CHA2DS2-Vasc Score Combined with Serum Fibrinogen-to-Albumin Ratio in Coronary Heart Disease

作　　者：吴泽群 张晶晶[1] 朱华良 丁旵东[1] 

机构地区：[1]安徽医科大学第二附属医院老年心血管内科,安徽 合肥

出　　处：《临床医学进展》2023年第1期1139-1145,共7页Advances in Clinical Medicine

摘　　要：目的:探讨CHA2DS2-Vasc评分联合血清维蛋白原和白蛋白比值(fibrinogen to albumin ratio, FAR)对冠心病(coronary heart disease, CHD)的诊断价值。方法:纳入2017/01/01~2019/01/01期间于安徽医科大学第二附属医院老年心血管内科行冠脉造影术(coronary angiography, CAG)检查的患者185例,其中明确诊断为冠心病116例,非冠心病69例。收集患者的临床资料,所有患者计算FAR值,评估CHA2DS2-Vasc评分。以发生冠心病为因变量,年龄、高血压、糖尿病、Fib、FAR、空腹血糖及CHA2DS2-Vasc评分作为自变量建立logistic回归模型,采用受试者工作特征曲线(receiver operating curve, ROC)评估CHA2DS2-Vasc评分联合FAR对冠心病的诊断价值。结果:两组年龄、高血压、糖尿病、Fib、FAR、空腹血糖及CHA2DS2-Vasc评分差异有统计学意义(P 2DS2-Vasc评分及FAR与CHD的发生呈独立正相联(P 2DS2-Vasc评分、FAR单项及联合诊断的效能,结果显示CHA2DS2-Vasc评分的曲线下面积(area under curve, AUC)为0.656 (95% CI 0.575~0.736),P 2DS2-Vasc评分联合FAR的AUC为0.702 (95% CI 0.624~0.780),敏感度79.3%,特异性52.2%,cut-off值0.552。结论:与CHA2DS2-Vasc评分及FAR相比,CHA2DS2-Vasc联合血清FAR对患者发生冠心病具有更好的临床评估价值。Objective: To explore the value of CHA2DS2-Vasc score combined with serum Fibrinogen-to-Albumin Ratio (FAR) in the diagnosis of coronary heart disease (CHD). Methods: 185 patients who underwent coronary angiography (CAG) in the Department of Geriatric Cardiology at the Second Affiliated Hos-pital of Anhui Medical University from 2017/01/01 to 2019/01/01 were included. Among them, 116 patients were diagnosed with coronary heart disease, 69 patients without coronary heart dis-ease. Clinical data were collected from patients, and all patients were calculated for FAR values to assess CHA2DS2-Vasc scores. A logistic regression model was established with the occurrence of cor-onary heart disease as the dependent variable, age, hypertension, diabetes, Fib, FAR, fasting blood glucose and CHA2DS2-Vasc score as independent variables, and the receiver operating curve (ROC) was used to evaluate the diagnostic value of CHA2DS2-Vasc score combined with FAR for coronary heart disease. Results: There were significant differences in age, hypertension, diabetes, Fib, FAR, fasting blood glucose and CHA2DS2-Vasc scores between the two groups (P CHA2DS2-Vasc scores and the occurrence of FAR and CHD were independently positively correlated (P CHA2DS2-Vasc scores, FAR and CHA2DS2-Vasc-FAR score for diagnosis of CHD. The area under curve (AUC) of CHA2DS2-Vasc scores were 0.656 (95% CI 0.575~0.736, P CHA2DS2-Vasc score combined with FAR was 0.702 (95% CI 0.624~0.780), sensitivity 79.3%, specificity 52.2%, cut-off value 0.552. Con-clusion: Compared with CHA2DS2-Vasc and FAR, CHA2DS2-Vasc combined with serum FAR has better clinical evaluation value for coronary heart disease in patients.

关 键 词：冠心病 冠状动脉造影术 CHA₂DS₂-Vasc 纤维蛋白/白蛋白比值 

分 类 号：R54[医药卫生—心血管疾病]