达格列净联合二甲双胍对超重及肥胖2型糖尿病患者体脂含量及肌肉含量的影响  

Effect of Dapagliflozin Combined with Metformin on Fat and Muscle Mass in Overweight and Obese Patients with Type 2 Diabetes

作　　者：张静文 牛佳鹏[1] 王静[1] 王斐[1] 

机构地区：[1]青岛大学附属医院内分泌科,山东 青岛

出　　处：《临床医学进展》2023年第2期2461-2467,共7页Advances in Clinical Medicine

摘　　要：目的:探究达格列净联合二甲双胍对超重及肥胖2型糖尿病患者体脂含量及肌肉含量的影响。方法:纳入于青岛大学附属医院门诊就诊并完成3个月随访的超重及肥胖2型糖尿病患者33例,分成两组,一组给予单用二甲双胍治疗作为对照组(13例),另一组在二甲双胍的基础上联合达格列净治疗作为观察组(20例)。两组均进行糖尿病教育,连续用药3个月后评估两组治疗前、后的血糖指标[空腹血糖(FBG)、糖化血红蛋白(HbA1c)]及观察指标[体重、体重指数(BMI)、腰围、腰臀比、体脂含量、内脏脂肪指数(VFI)1、肌肉含量]的变化。结果:入组前,两组患者的FBG、HbA1c、体重、BMI、腰围、腰臀比、体脂含量、VFI、肌肉含量的基线值无显著差异(P > 0.05)。治疗3个月后,观察组的FPG、HbA1c较治疗前显著降低(P 0.05);两组患者的体重、BMI、腰围、腰臀比、体脂含量、VFI较治疗前均显著降低(P < 0.05);观察组与对照组的肌肉含量较治疗前降低未达到显著性差异(p ≥ 0.05)。结论:达格列净联合二甲双胍对超重及肥胖2型糖尿病患者的降糖效果明显优于单用二甲双胍,同时还具有减轻体重、减少体脂含量的作用,而对肌肉含量的减少未达到显著性差异。Objective: To investigate the effect of dapagliflozin combined with metformin on fat and muscle mass in overweight and obese patients with type 2 diabetes. Methods: A total of 33 overweight and obese patients with type 2 diabetes were recruited from the Outpatient Department of the Affiliat-ed Hospital of Qingdao University and followed up for 3 months, one group was treated with met-formin alone as control group (N = 13), and the other group was treated with metformin plus dapagliflozin as observation group (N = 20). Diabetes education was carried out in both groups, af-ter 3 months of continuous treatment, the blood glucose indexes [FBG, HbA1c], and observation in-dicators [body weight, body mass index (BMI), waist circumference, waist-to-hip ratio, body fat con-tent, visceral fat index (VFI), and muscle content] were evaluated before and after treatment in both groups. Results: The baseline values of FBG, HbA1c, body weight, BMI, waist circumference, waist-hip ratio, body fat content, VFI and muscle content were not significantly different between the two groups (P > 0.05). After treatment for 3 months, FPG and HbA1c in the observation group were significantly lower than those before treatment (P 0.05);the body weight, BMI, waist circumference, waist-hip ratio, body fat content and VFI of the two groups were significantly lower than those before treatment (P < 0.05), and the muscle contents of the observation group and the control group were not significantly lower than those before treatment (P ≥ 0.05). Conclusions: Dapagliflozin combined with metformin is significantly better than metformin alone in reducing blood sugar in overweight and obese patients with type 2 diabetes, and has the effect of reducing weight and fat content, there was no significant reduction in muscle content.

关 键 词：达格列净 二甲双胍 2型糖尿病 超重及肥胖 体脂含量 肌肉含量 

分 类 号：R58[医药卫生—内分泌]