成纤维细胞生长因子在骨关节炎的研究进展  

Research Progress of Fibroblast Growth Factor Signalling in Osteoarthritis

作　　者：何子轩 陈海啸[2] 

机构地区：[1]浙江大学医学院,浙江 杭州 [2]浙江大学附属台州医院,浙江 临海

出　　处：《临床医学进展》2023年第2期2543-2549,共7页Advances in Clinical Medicine

摘　　要：骨关节炎是一种退行性慢性关节疾病,目前临床治疗效果不佳,严重影响病人的生活质量。成纤维细胞生长因子信号通路不仅参与调节正常的生理过程,在骨关节炎的发生发展中也扮演关键角色,尤其是在软骨代谢及合成方面意义重大。本文就近年来FGF/FGFR信号通路参与骨关节炎发生发展、软骨及软骨下骨退变机制以及与该通路相关的靶点在骨关节炎治疗中的研究现状进行综述。Osteoarthritis (OA) is a degenerative chronic joint disease. Although OA seriously affects the quality of life of patients, no effective treatment options are provided so far. Fibroblast growth factor sig-naling pathway is not only involved in regulating normal physiological processes, but also related to the occurrence and development of osteoarthritis, especially in cartilage metabolism and synthesis. In this review, recent studies about FGF/FGFR signaling pathway in the development of osteoarthri-tis, the mechanism of cartilage and subchondral bone degeneration, and the treatment of osteoar-thritis related to this pathway were summarized.

关 键 词：成纤维细胞生长因子 骨关节炎 软骨退化 

分 类 号：R68[医药卫生—骨科学]