轮状病毒与肠道菌群的相互作用  

Interaction between Rotavirus and Intestinal Flora

作　　者：邝文涛 杨学磊[2] 

机构地区：[1]新疆医科大学研究生院,新疆 乌鲁木齐 [2]新疆维吾尔自治区人民医院医学研究与转化中心,新疆 乌鲁木齐

出　　处：《临床医学进展》2023年第3期3392-3401,共10页Advances in Clinical Medicine

摘　　要：轮状病毒是引起全球学龄前儿童急性腹泻的主要病原体,过去的很多研究已经揭示了轮状病毒和肠道菌群之间存在一系列复杂的相互作用。轮状病毒感染会暂时改变肠道菌群的组成,同时益生菌给药也可以改善患者的胃肠道症状。目前轮状病毒疫苗是预防轮状病毒感染的最有效手段。有研究表明肠道菌群对疫苗使用也会产生一定的影响。现对轮状病毒与肠道菌群相互作用及肠道菌群对轮状病毒疫苗有效性影响作一综述。Rotavirus is the main pathogen of acute diarrhea in preschool children all over the world. many previous studies have revealed a series of complex interactions between rotavirus and intestinal flora. Rotavirus infection temporarily changes the composition of intestinal flora, and probiotic ad-ministration can also improve gastrointestinal symptoms. At present, rotavirus vaccine is the most effective means to prevent rotavirus infection. Some studies have shown that intestinal flora can al-so have a certain impact on the use of vaccine. This paper reviews the interaction between rotavirus and intestinal flora and the effect of intestinal flora on the effectiveness of rotavirus vaccine.

关 键 词：轮状病毒 肠道菌群 相互作用 轮状病毒疫苗 

分 类 号：R72[医药卫生—儿科]