异基因造血干细胞移植治疗儿童肝炎后极重型再生障碍性贫血导致难治性巨细胞病毒肺炎所致死亡1例  

A Case of Death Caused by Refractory Cytomegalovirus Pneumonia after Allogeneic Hematopoietic Stem Cell Transplantation for Treatment of Severe Aplastic Anemia after Hepatitis in Children

作　　者：王亚宁 徐惠芳 陈璐璐[2] 黄宗宣[2] 张颢[3] 陶艳玲[2] 

机构地区：[1]济宁医学院研究生院,山东 济宁 [2]济宁医学院附属医院儿童血液科血液研究所,山东 济宁 [3]济宁医学院附属医院血液科,山东 济宁

出　　处：《临床医学进展》2023年第3期3907-3910,共4页Advances in Clinical Medicine

摘　　要：异基因造血干细胞移植(allo-HSCT)是再生障碍性贫血的重要治疗方法。常见的并发症是机会性感染和移植物抗宿主病(GVHD)。巨细胞病毒(CMV)是机会性感染最常见的原因之一,也是导致移植相关发病率和死亡率的重要原因。本文报道一例肝炎后再生障碍性贫血行异基因造血干细胞移植(亲缘半相合)术后巨细胞病毒感染所致重症肺炎导致死亡的患儿。给予早期、足量、联合、长期的抗病毒治疗后,仍不能阻止病毒在体内的复制,最终导致死亡。Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment for aplastic anemia. Common complications are opportunistic infections and graft-versus-host disease (GVHD). Cytomegalovirus (CMV) is one of the most common causes of opportunistic infection and is an important cause of transplant-related morbidity and mortality. In this paper, a child with severe pneumonia due to cytomegalovirus infection following an allogeneic hematopoietic stem cell transplantation (relatives semi-conjugated) is reported in post-hepatitis aplastic anemia. After giving early, adequate, combined, long-term antiviral therapy, it still cannot stop the replication of the virus in the body, which eventually leads to death.

关 键 词：异基因 造血干细胞移植 再生障碍性贫血 巨细胞病毒感染 

分 类 号：R55[医药卫生—血液循环系统疾病]