乙型肝炎表面抗原清除后与疾病长期临床结局的关系  

Relationship between Hepatitis B Surface Antigen Clearance and Long-Term Clinical Outcomes

作　　者：胡小小 石小枫[1] 

机构地区：[1]重庆医科大学附属第二医院感染科,重庆

出　　处：《临床医学进展》2023年第3期4123-4128,共6页Advances in Clinical Medicine

摘　　要：早在《2015慢性乙型肝炎防治指南》中已明确指出,慢性乙型肝炎的临床治愈已被作为理想的治疗终点。无论是表面抗原自发清除还是通过抗病毒治疗后实现的表面抗原清除,一部分慢乙肝患者已经实现了乙肝的临床治愈,但乙肝表面抗原清除并不是一劳永逸的,HBsAg清除的持久性及临床结局的改善相关研究有限,本文旨在就血清HBsAg清除后的长期临床结局行综述。As already stated in the 2015 Guidelines for the Prevention and Treatment of Chronic Hepatitis B, clinical cure of chronic hepatitis B has been regarded as the ideal therapeutic endpoint. Some pa-tients with chronic hepatitis B have achieved clinical cure of hepatitis B, whether it is spontaneous clearance of surface antigen or the clearance of surface antigen after antiviral treatment. However, hepatitis B surface antigen clearance is not permanent and relevant studies on the persistence of HBsAg clearance and improvement of clinical outcome are limited. This article aims to review the long-term clinical outcomes after serum HBsAg clearance.

关 键 词：慢性乙型肝炎 临床治愈 HBsAg清除 临床结局 

分 类 号：R51[医药卫生—内科学]