乙型肝炎病毒感染与自身免疫的相关性研究  

Relative Study between Hepatitis B Virus Infection and Autoimmunity

作　　者：李羽 胡树恒 韩倩 于江[2] 李莉[2] 申爱华[2] 程一鸣 周建伟[2] 

机构地区：[1]济宁医学院临床医学院,山东 济宁 [2]济宁医学院附属医院检验科,山东 济宁

出　　处：《临床医学进展》2023年第3期4221-4226,共6页Advances in Clinical Medicine

摘　　要：目的:研究乙型肝炎病毒(HBV)感染与自身免疫发生的相关性。方法:选取100例HBV感染者作为实验组,检测乙肝五项定量指标和病毒DNA (HBV-DNA);同时选取50例健康体检者作为对照组。两组均采用间接免疫荧光方法进行抗核抗体(ANA)检测。结果:实验组ANA阳性率49%,与对照组(24%)比较,差异有统计学意义(P 2且5拷贝标本中ANA阳性23例(53.5%),≥1.0 × 105且7拷贝的9例(64.3%),≥1.0 × 107且9拷贝的8例(44.4%);各组间比较统计学无明显差异(P > 0.05)。结论:乙型肝炎病毒感染可以导致自身免疫的发生,但不同的乙肝五项定量模式和血清HBV-DNA载量与自身免疫无明显相关性。Objective: To study the possible relativity between hepatitis B virus (HBV) infection and autoim-munity. Methods: 100 patients infected with HBV were selected as the experimental group, serum five quantitative indicators and HBV-DNA of hepatitis B virus were detected. Meanwhile, 50 healthy subjects were selected as control group. Anti-nuclear antibody (ANA) was detected with indirect immunofluorescence assay. Results: The positive rate of ANA in the experimental group was 49%, which was significantly higher than 24% of the control group (P 2 and 5 copies, 9 cases (64.3%) for ≥1.0 × 105 and 7 copies, 8 cases (44.4%) for ≥1.0 × 107 and 9 copies. There was no significant difference among all groups (P > 0.05). Conclusion: Hepatitis B virus infection can lead to the occurrence of autoimmunity, but the relativity between autoimmunity between HBV five quantitative indices and serum HBV-DNA load is not found in this study.

关 键 词：乙型肝炎病毒 乙型肝炎五项定量 病毒载量 抗核抗体 自身免疫 

分 类 号：R51[医药卫生—内科学]