胆道菌群与胆结石病相关性的研究进展  

Research Progress on the Relationship between Biliary Flora and Gallstone Disease

作　　者：周陈阳 任利[1] 

机构地区：[1]青海大学附属医院肝胆胰外科,青海 西宁

出　　处：《临床医学进展》2023年第4期5348-5353,共6页Advances in Clinical Medicine

摘　　要：胆结石病是一种常见的胃肠道良性疾病,近年来,随着人民生活水平的提高与饮食习惯的改变,其发病率也逐步升高,胆结石病目前仍然是一个高成本、具有社会意义的公共卫生问题。胆结石病是一种由多种致病因素引起的疾病,胆结石生成的具体病因及发病机制目前仍未完全明晰。而随着对人类及动物模型进行的大量研究,证实了胆道菌群在胆结石发病机制中的存在着重要意义。本文即对胆道菌群及其各影响因素、菌群及其代谢产物参与结石形成的详细机制等相关研究成果进行综述,旨在为胆结石病的预防及治疗提供新的方向。Cholelithiasis is a common benign gastrointestinal disease. In recent years, with the improvement of people’s living standards and changes in their eating habits, its incidence rate has gradually in-creased. Cholelithiasis is still a high cost and socially significant public health problem. Cholelithia-sis is a disease caused by a variety of pathogenic factors. The specific cause and pathogenesis of gallstone formation are still unclear. With a large number of studies on human and animal models, it has been confirmed that the existence of biliary flora in the pathogenesis of gallstones is of great significance. In this paper, we will review the research results of bile duct flora and its influencing factors, and the detailed mechanism of the flora and its metabolites involved in the formation of gallstones, in order to provide a new direction for the prevention and treatment of gallstones.

关 键 词：胆道菌群 胆结石病综述 

分 类 号：R65[医药卫生—外科学]