CD4⁺T淋巴细胞在侵袭性肺部真菌感染的研究进展  

Research Progress of CD4+T Lymphocytes in Invasive Pulmonary Fungal Infection

作　　者：高亚梅 徐思成[1] 

机构地区：[1]新疆医科大学第一附属医院,新疆 乌鲁木齐

出　　处：《临床医学进展》2023年第4期6572-6576,共5页Advances in Clinical Medicine

摘　　要：威胁生命的侵袭性肺部真菌感染(Invasive pulmonary fungal infection)的发病率正在增加,特别是在免疫功能低下的患者中,成功解决IFD需要多种不同的免疫细胞参与。本文主要综述了人类CD4+T淋巴细胞对IFD主要病原体的免疫反应的证据,以及淋巴细胞群在抗真菌免疫中作用的最新发现和见解,以加深淋巴细胞在抗真菌中作用机制的理解,为改进抗真菌治疗提供新的思路。The incidence rate of life threatening invasive pulmonary fungal infection is increasing, especially in patients with low immune function. A variety of different immune cells are needed to successfully solve IFD. This article mainly reviews the evidence of the immune response of human CD4+T lym-phocytes to the main pathogens of IFD, as well as the latest findings and insights on the role of lym-phocyte groups in antifungal immunity, in order to deepen the understanding of the mechanism of lymphocytes in antifungal immunity, and provide new ideas for improving antifungal therapy.

关 键 词：CD4⁺T淋巴细胞 侵袭性真菌病 侵袭性肺部真菌感染 

分 类 号：R51[医药卫生—内科学]