新型生物标志物在开颅术后颅内感染诊断中的研究进展  

Research Progress of Novel Biomarkers in the Diagnosis of Intracranial Infection after Craniotomy

作　　者：郭飞 李坤正[1] 

机构地区：[1]青海大学附属医院神经外科,青海 西宁

出　　处：《临床医学进展》2023年第6期8979-8985,共7页Advances in Clinical Medicine

摘　　要：神经外科术后细菌性脑膜炎(post-neurosurgical bacterial meningitis, PNBM)是开颅术后最常见的并发症,可导致显著的发病率和死亡率;虽然无菌技术越发成熟,但细菌性脑膜炎仍然是神经外科手术过程中不可避免的障碍,且传统生物标志物、临床症状及影像学检查对于细菌性及无菌性炎症鉴别受限,因此本文就新型生物标志物以及脑脊液基因检测在PNBM早期诊断的研究进展进行综述。Post-neurosurgical bacterial meningitis (PNBM) is the most common complication after craniotomy, which can lead to significant morbidity and mortality. Although aseptic technology is becoming more mature, bacterial meningitis is still an unavoidable obstacle in neurosurgery, and traditional biomarkers, clinical symptoms and imaging examinations are limited in the differentiation of bac-terial and aseptic inflammation, so this article reviews the research progress of novel biomarkers in the early diagnosis of PNBM.

关 键 词：脑膜炎 神经外科 细菌感染 无菌性炎症 生物标志物 

分 类 号：R65[医药卫生—外科学]