脂联素及其基因多态性与糖尿病并发症之间的相关性研究  

Study on the Correlation between Adiponectin and Its Gene Polymorphism and Diabetic Complications

作　　者：焦怡锋 巴应贵[1] 

机构地区：[1]青海大学附属医院肾病科,青海 西宁

出　　处：《临床医学进展》2023年第6期9247-9256,共10页Advances in Clinical Medicine

摘　　要：脂联素(adiponectin)由脂肪细胞分泌,在糖脂代谢、能量代谢、以及心血管系统的生理调节和病理生理中都起着一定作用,与糖尿病、高血压和代谢综合征等疾病密切相关。脂联素在不同种族、年龄、性别的群体中的表达有差异。脂联素具有保护心血管的作用,可预示糖尿病大血管严重程度。本文就脂联素的受体、单核苷酸多态性,脂联素与糖尿病各种并发症的相关性进行了综述。Adiponectin is secreted by adipocytes and plays a role in glycolipid metabolism, energy metabolism, physiological regulation and pathophysiology of the cardiovascular system. It is closely related to diabetes, hypertension and metabolic syndrome. The expression of adiponectin in different ethnic, age and gender groups is different. Adiponectin has a cardiovascular protection effect, which can predict the severity of large vessels in diabetes. This article reviews the receptor of adiponectin, single nucleotide polymorphism, and the correlation between adiponectin and various complica-tions of diabetes.

关 键 词：脂联素 糖尿病 单核苷酸多态性(SNPs) 并发症 

分 类 号：R58[医药卫生—内分泌]