川贝母及其主要成分抗炎作用研究进展  

Advances in the Study of Anti-Inflammatory Effects of Fritillariae cirrhosae Bulbus and Its Main Components

作　　者：林语诗 岳鸿溢 王平义 张建安 贾云飞 常森昊 王兆博 扎西措姆 李文华 

机构地区：[1]西藏民族大学医学部,陕西 咸阳

出　　处：《临床医学进展》2023年第6期10212-10219,共8页Advances in Clinical Medicine

摘　　要：背景:川贝母基源于百合科贝母属,常见于多种植物的干燥鳞茎,其主要活性成分为异甾体类生物碱,具有镇咳、抗炎、祛痰、镇痛、抗癌、抗氧化等多种功效。近年来,其抗炎作用越来越受到关注,成为炎症疾病防治的一个研究热点。目的:本文通过概述川贝母及其活性成分主要是贝母辛在哮喘、慢性阻塞性肺病、急性肺损伤疾病等中的治疗作用,以期为川贝母的进一步临床应用提供理论依据。方法:运用计算机检索中国知网、万方、PubMed、SinoMed数据库,对相关文献进行归纳整理与分析。检索的关键词为“川贝母、贝母辛、哮喘、急性肺损伤、慢性阻塞性肺病、癌症”。结果和结论:川贝母可以通过抑制JAK/STAT、MAPK等信号通路的激活,降低炎症因子和炎症细胞的聚集,从而起到抗炎作用。在炎症相关疾病中川贝母及其活性提取物的抗炎作用,具有多效应、多靶点、多信号通路的特点,且其具体作用机制较为复杂仍有待我们进一步探索。Background: Fritillariae cirrhosae Bulbus derived from the genus Fritillaria in the lily family and is commonly found on the dried bulbs of a variety of plants. Its main active ingredient is isosteric al-kaloids, which have various effects such as cough suppressant, anti-inflammatory, expectorant, an-algesic, anti-cancer and antioxidant. In recent years, its anti-inflammatory effects have received in-creasing attention and become a research hotspot in the prevention and treatment of inflammatory diseases. Objective: This paper provides a theoretical basis for the further clinical application of Fri-tillariae cirrhosae Bulbus and its active ingredients, mainly bemusine, in asthma, chronic obstruc-tive pulmonary disease and acute lung injury diseases by outlining their therapeutic effects. Meth-ods: We used the computer to search the databases of China Knowledge Network, Wanfang, PubMed and SinoMed to summarize and analyze the relevant literature. The keywords searched were “Fri-tillariae cirrhosae Bulbus, Peimisine, Asthma, Acute Lung Injury, COPD, Cancer”. Results and Con-clusions: Fritillariae cirrhosae Bulbus can reduce the aggregation of inflammatory factors and in-flammatory cells by inhibiting the activation of JAK/STAT, MAPK and other signaling pathways, thus exerting anti-inflammatory effects. The anti-inflammatory effects of Fritillariae cirrhosae Bulbus and its active extracts in inflammation-related diseases are characterized by multiple effects, mul-tiple targets and multiple signaling pathways, and their specific mechanisms of action are complex and still need to be further explored.

关 键 词：川贝母 贝母辛 抗炎 哮喘 慢性阻塞性肺病 急性肺损伤 癌症 

分 类 号：R28[医药卫生—中药学]