CaSR对糖尿病并发症型的调控作用研究进展  

Research Progress in the Regulation of CaSR on Complications of Diabetes

作　　者：刘婧文 

机构地区：[1]黑龙江中医药大学基础医学院,黑龙江 哈尔滨

出　　处：《临床医学进展》2023年第7期11382-11386,共5页Advances in Clinical Medicine

摘　　要：糖尿病是一种代谢类疾病,近年来随着人们生活水平的逐渐增高,糖尿病患者人数日益增长,我国是全世界患二型糖尿病人数最多的国家。糖尿病会使许多器官受到损伤,包括心脏、肾脏、睾丸、脑部神经元以及周围神经等,进而导致糖尿病并发症的发生。钙敏感受体(CaSR)是一种C类G蛋白偶联受体,常与一些钙稳态类疾病相关,如原发性和继发性甲状旁腺功能亢进症、恶性肿瘤高钙血症、常染色体显性遗传性低钙血症等。本文主要整理了CaSR在糖尿病并发症中发挥的调控作用,为CaSR作为疾病治疗靶点提供新思路。Diabetes is a metabolic disease. In recent years, with the gradual increase of people’s living stand-ards, the number of patients with diabetes is growing. China has the largest number of type 2 dia-betes patients in the world. Diabetes can damage many organs, including the heart, kidney, testis, brain neurons and peripheral nerves, which will lead to complications of diabetes. Calcium sensitive receptor (CaSR) is a class C G protein-coupled receptor, which is often associated with some calcium homeostasis diseases, such as primary and secondary hyperparathyroidism, malignant tumor hy-percalcemia, autosomal dominant hereditary hypocalcemia, etc. This article mainly reviews the regulatory role of CaSR in the complications of diabetes, and provides new ideas for CaSR as a target for disease treatment.

关 键 词：糖尿病并发症 钙敏感受体 糖尿病 研究进展 

分 类 号：R58[医药卫生—内分泌]