基于网络药理学及分子对接探究扫白茴风丸治疗白癜风的作用机制  

Exploring the Mechanism of Saobai Huifeng Pill in Treating Vitiligo Based on Network Pharmacology and Molecular Docking

作　　者：倪乾越 

机构地区：[1]黑龙江中医药大学研究生院,黑龙江 哈尔滨

出　　处：《临床医学进展》2023年第7期11906-11917,共12页Advances in Clinical Medicine

摘　　要：目的:基于网络药理学探究扫白茴风丸治疗白癜风的潜在机制。方法:利用TCMSP数据库、SwissADME、Swisstarget数据库获取扫白茴风丸中主要成分麻黄、桂枝、防风、荆芥、淫羊藿的有效成分及其靶点;通过Genecard、OMIM、TTD以及Drugbank数据库收集白癜风的相关靶点;将药物靶点与疾病靶点取交集,进而得到扫白茴风丸治疗白癜风的潜在作用靶点;利用Cytoscape 3.7.2软件构建“疾病–药物–成分–靶点”网络;通过Metascape基因注释与分析网站对核心靶点进行GO功能和KEGG信号通路富集分析;利用PyMOL2.3.0和Ligplot V2.2.5对对接结果进行相互作用模式分析。结论:扫白茴风丸通过多味中药、多组成分、多靶点、多通路发挥作用以治疗白癜风,其作用机制与炎症反应、氧化反应等途径实现白癜风治疗,本研究为其进一步的药理研究提供相关参考。Objective: To explore the potential mechanism of Saobai Huifeng Pill in treating vitiligo based on network pharmacology. Methods: TCMSP database, SwissADME, Swisstarget database were used to obtain the active ingredients and targets of the main components of Ephedra, Guizhi, Fangfeng, Schizonepeta, and Epimedium in Saobai Huifeng Pill;related targets of vitiligo were collected by Genecard, OMIM, TTD and Drugbank database. The drug target and the disease target are inter-sected, and then potential target of treating vitiligo with Saobai Huifeng Pill is obtained. The net-work of “disease-drug-component-target” is constructed by using Cytoscape 3.7.2 software;GO func-tion and KEGG signal pathway enrichment of core targets were analyzed through Metascape gene annotation and analysis website. PyMOL2.3.0 and Ligplot V2.2.5 were used to analyze the interac-tion mode of the docking results. Conclusion: Saobai Huifeng Pill plays a role in the treatment of viti-ligo through multiple Chinese medicines, multiple components, multiple targets and multiple channels. Its mechanism of action is related to inflammatory reaction and oxidation reaction to re-alize the treatment of vitiligo. This study provides relevant reference for further pharmacological research.

关 键 词：扫白茴风丸 白癜风 网络药理学 作用机制 信号通路 

分 类 号：R75[医药卫生—皮肤病学与性病学]