脂毒性与糖尿病心脏病的研究进展  

Research Progress of Lipid Toxicity and Diabetic Heart Disease

作　　者：王慧娟 左小芹[2] 

机构地区：[1]青海大学研究生院,青海 西宁 [2]青海大学附属医院老年科,青海 西宁

出　　处：《临床医学进展》2023年第8期13074-13079,共6页Advances in Clinical Medicine

摘　　要：糖尿病心脏病是糖尿病患者严重的并发症之一。最近的研究表明,糖尿病脂质代谢紊乱引起的心肌细胞脂毒性可能是糖尿病心脏病发生的关键因素。脂毒性可以诱发心肌炎症、氧化应激、胰岛素抵抗、心肌纤维化、微血管功能障碍,导致细胞凋亡、心肌纤维化和舒张功能障碍,导致糖尿病心脏病。糖尿病心脏病最终可进展为心力衰竭,导致患者死亡率增加。目前,心肌细胞脂毒性导致糖尿病心脏病发生发展的具体机制尚不明确。因此,本文就脂毒性在糖尿病心脏病发病机制中的作用及可能机制进行综述,以期为基础研究和临床诊疗提供参考。Diabetic heart disease is one of the serious complications of diabetic patients. Recent studies have shown that cardiomyocyte lipid toxicity caused by diabetic lipid metabolism disorder may be a key factor in the occurrence of diabetic heart disease. Lipid toxicity can induce myocardial inflammation, oxidative stress, insulin resistance, myocardial fibrosis, microvascular dysfunction, resulting in apoptosis, myocardial fibrosis and diastolic dysfunction, leading to diabetic heart disease, can eventually progress to heart failure, leading to increased mortality in patients. At present, the spe-cific mechanism of cardiomyocyte lipid toxicity leading to the development of diabetic heart disease is not clear. Therefore, this article reviews the role and possible mechanism of lipid toxicity in the pathogenesis of diabetic heart disease, in order to provide reference for basic research and clinical diagnosis and treatment.

关 键 词：糖尿病 脂毒性 糖尿病性心脏病 

分 类 号：R54[医药卫生—心血管疾病]