选择素蛋白糖基修饰及其与慢性炎症疾病研究进展  

Progress in Protein Modification of Selectin and Its Relationship with Chronic Inflammatory Diseases

作　　者：黄达 潘兴寿 梁烨 李近都 李天资 

机构地区：[1]右江民族范附属医院心血管内科,广西 百色 [2]广西医科大学附属肿瘤医院肝胆胰脾外科,广西 南宁

出　　处：《临床医学进展》2023年第8期13280-13288,共9页Advances in Clinical Medicine

摘　　要：选择素蛋白是普遍存在于真核生物中的一类非免疫来源的糖蛋白,具有凝集细胞、特异性糖基识别与结合等化学特性,主要参与白细胞与血管内皮细胞之间的识别与粘着,在促进有丝分裂、细胞连接与粘附、肿瘤、免疫调节和病毒感染等方面发挥重要作用。近年来,选择凝蛋白质修饰在高血压,动脉粥样硬化,心肌梗死,凝血障碍和糖尿病等中的研究取得许多新进展,现综述如下。Selectin protein is a kind of non-immune glycoproteins, which exists in eukaryotes. It has many chemical properties, such as agglutinating cells, specific recognition and binding of glycosyl groups, etc., it is mainly involved in the recognition and adhesion between white blood cells and Endothe-lium cells, and plays an important role in the promotion of mitosis, cell connection and adhesion, tumor, immune regulation and viral infection. In recent years, many new advances have been made in the study of selective coagulation protein modification in hypertension, arteriosclerosis, myocar-dial infarction, coagulation disorders, and diabetes mellitus. The summary is as follows.

关 键 词：选择素蛋白 糖基化修饰 细胞粘附 炎症疾病 

分 类 号：R54[医药卫生—心血管疾病]