膝骨关节炎中软骨下骨的异常改变  

Abnormal Changes of Subchondral Bone in Knee Osteoarthritis

作　　者：鲁群 何晓宏[2] 石庆云 

机构地区：[1]青海大学医学院,青海 西宁 [2]青海大学附属医院康复医学科,青海 西宁

出　　处：《临床医学进展》2023年第8期13525-13533,共9页Advances in Clinical Medicine

摘　　要：膝骨关节炎(knee osteoarthritis KOA)主要由关节软骨和软骨下骨的退变引起。软骨下骨在关节功能正常发挥及结构完整中占据重要地位,软骨下骨的病理改变在KOA的发生和发展过程中的作用在近年来得到了公认,被认为是有潜力的治疗KOA的靶点。本文就软骨下骨在KOA中所发生的一系列病理变化包括:骨重塑,微骨折,分子结构异常、软骨下骨髓水肿、软骨下囊肿等方面进行综述,为KOA的治疗提供治疗理论依据。Knee osteoarthritis (KOA) is mainly caused by degeneration of articular cartilage and subchondral bone. Subchondral bone plays an important role in the normal function and structural integrity of joints. In recent years, the role of pathological changes of subchondral bone in the occurrence and development of KOA has been recognized as a potential target for the treatment of KOA. In this pa-per, the pathological changes of subchondral bone in KOA, including bone remodeling, microfrac-ture, molecular structure abnormalities, subchondral bone marrow edema, subchondral cyst and other aspects were reviewed, so as to provide theoretical basis for the treatment of KOA.

关 键 词：膝骨关节炎 软骨下骨 骨重塑 微骨折 骨髓水肿样变 

分 类 号：R68[医药卫生—骨科学]