MTHFR、MTRR基因多态性与不明原因复发性流产相关性的Meta分析  

Meta-Analysis of the Correlation between MTHFR, MTRR Gene Polymorphisms and Unexplained Recurrent Spontaneous Abortion

作　　者：翟焕玲 

机构地区：[1]济宁医学院附属金乡县人民医院生殖医学科,山东 金乡

出　　处：《临床医学进展》2023年第9期14061-14074,共14页Advances in Clinical Medicine

摘　　要：目的:通过meta分析研究MTHFR基因C677T、A1298C和MTRR基因A66G三个位点基因多态性与不明原因复发性流产(unexplained recurrent spontaneous abortion, URSA)的相关性。方法:通过检索数据库PubMed、EMBASE及Web of Science,共检索到953篇文献,其中PubMed 213篇、EMBASE 439篇、Web of Science 301篇,通过阅读文献,按照筛查标准进行初筛,最终共纳入43篇文献进行meta分析。结果:Meta分析提示叶酸代谢酶MTHFR、MTRR基因的三个位点的基因突变率(MTHFR C677T位点CC vs. CT + TT、A1298C位点AA vs. AC + CC、MTRR A66G位点AA vs. AG + GG)在URSA组与对照组之间存在显著差异(P < 0.05)。对于MTHFR C667T CC vs. CT + TT组,共纳入35篇文献,合并后的OR = 1.21,95% CI [1.10~1.34],对于MTHFR A1298C AA vs. AC + CC组,共纳入14篇文献,合并后的OR = 1.18,95% CI [1.04~1.35],对于MTRR A66G AA vs. AG + GG组,共纳入3篇文献,合并后的OR = 1.52,95% CI [1.19~1.94],即URSA病例组MTHFR C677T基因位点、A1298C基因位点和MTRR A66G基因位点的突变率显著高于对照组。结论:本meta荟萃分析结果提示MTHFR基因的C677T、A1298C位点和MTRR基因的A66G位点与叶酸代谢有关。Objective: To investigate the correlation between genetic polymorphisms at three loci of MTHFR gene C677T, A1298C, and MTRR gene A66G and unexplained recurrent spontaneous abortion (URSA) through meta-analysis. Method: By searching the databases PubMed, EMBASE, and Web of Science, a total of 953 articles were retrieved, including PubMed 213 articles, EMBASE 439 articles, and Web of Science 301 articles. After reading the literature, preliminary screening was conducted according to screening criteria, and a total of 43 articles were included for meta-analysis. Result: Meta-analysis showed that the mutation rate of three loci of MTHFR and MTRR genes (MTHFR C677T locus CC vs. CT + TT, A1298C locus AA vs. AC + CC, MTRR A66G locus AA vs. AG + GG) was significantly different between URSA group and control group (P < 0.05). For the MTHFR C667T CC vs. CT + TT group, a total of 35 articles were included, with a combined OR of 1.21, 95% CI [1.10~1.34]. For the MTHFR A1298C AA vs. AC + CC group, a total of 14 articles were included, with a combined OR of 1.18, 95% CI [1.04~1.35]. For the MTRR A66G AA vs. AG + GG group, a total of 3 articles were in-cluded, with a combined OR of 1.52, 95% CI [1.19~1.94], which is the MTHFR C677T gene locus in the URSA case group. The mutation rates of A1298C gene locus and MTRR A66G gene locus were significantly higher than those of the control group. Conclusion: The results of this meta-analysis suggest that the C677T and A1298C loci of the MTHFR gene and the A66G locus of the MTRR gene are related to folate metabolism.

关 键 词：叶酸代谢酶 MTHFR MTRR 基因多态性 URSA 

分 类 号：R71[医药卫生—妇产科学]