ADAMTS-13调控急性心肌梗死的机制研究  

Study on the Mechanism of ADAMTS-13 Regulating Acute Myocardial Infarction

作　　者：古再丽努尔·霍加阿卜杜拉 阿卜杜如苏力·喀迪尔 彭辉[2] 

机构地区：[1]新疆医科大学研究生学院,新疆 乌鲁木齐 [2]新疆维吾尔自治区人民医院心血管内科,新疆 乌鲁木齐

出　　处：《临床医学进展》2023年第9期14297-14303,共7页Advances in Clinical Medicine

摘　　要：ADAMTS-13是一种金属蛋白酶,可特异性切割血管性血友病因子(VWF),从而防止白细胞过度募集,下调炎症和血栓的形成。ADAMTS-13与VWF现在被认为在越来越多的血管炎症和血栓形成的疾病中起重要作用,特别是在急性心肌梗死(AMI)中研究越来越深入。ADAMTS-13结构与功能和AMI发生机制密切相关。本篇综述主要阐述ADAMTS-13调控AMI的作用机制。ADAMTS-13 is a metalloproteinase secreted in the blood that can specifically cleave von Willebrand Factor (VWF), thereby preventing excessive recruitment of white blood cells and downregulating inflammation and thrombosis formation. ADAMTS-13 and VWF are now considered to play an im-portant role in an increasing number of vascular inflammation and thrombosis diseases, especially in the study of acute myocardial infarction (AMI). The structure and function of ADAMTS-13 are closely related to the mechanism of AMI occurrence. This review mainly elaborates on the mecha-nism of ADAMTS-13 in regulating acute myocardial infarction.

关 键 词：急性心肌梗死 ADAMTS-13 VWF 血栓形成 炎症反应 

分 类 号：R54[医药卫生—心血管疾病]