儿童糖尿病酮症酸中毒并发脑水肿的综述  

A Review of Diabetic Ketoacidosis Complicated with Cerebral Edema in Chil-dren

作　　者：薛洁[1] 买尔江古丽·阿布来克木 靳瑾[2] 

机构地区：[1]新疆医科大学第五临床医学院,新疆 乌鲁木齐 [2]新疆医科大学第五附属医院内分泌科,新疆 乌鲁木齐

出　　处：《临床医学进展》2023年第9期14574-14578,共5页Advances in Clinical Medicine

摘　　要：儿童糖尿病常以高血糖、代谢性酸中毒、酮体过量为特征的糖尿病酮症酸中毒(Diabetic ketoacidosis, DKA)急性起病,常伴有不同程度的循环容量衰竭,危及患儿生命。DKA救治过程中可能会发生低血糖、脑水肿等不良后果,其中酮症酸中毒并发的脑水肿是儿童DKA最严重、死亡率最高的并发症,幸存的患儿也可能会遗留永久性神经损伤,DKA有关脑水肿的发生机制非常复杂,本文对儿童糖尿病酮症酸中毒并发脑水肿的流行病学、病理生理机制、危险因素、临床表现、诊断及治疗进行综述。Diabetic ketoacidosis (DKA), which is characterized by hyperglycemia, metabolic acidosis and ke-tone body excess, is often accompanied by varying degrees of circulatory volume failure, endanger-ing the life of children. During the treatment of DKA, hypoglycemia, brain edema and other adverse consequences may occur, among which, brain edema complicated by ketoacidosis is the most seri-ous complication with the highest mortality in children with DKA, and children who survive may also suffer permanent neurological damage. The mechanism of brain edema related to DKA is very complex. This article reviews the epidemiology, pathophysiological mechanism, risk factors, clinical manifestations, diagnosis and treatment of diabetic ketoacidosis complicated with cerebral edema in children.

关 键 词：儿童 糖尿病酮症酸中毒 脑水肿 

分 类 号：R58[医药卫生—内分泌]