针刺镇痛机制的研究进展  

Research Progress on the Mechanism of Ac-upuncture Analgesia

作　　者：迪丽努尔·吐送托合提 黄志龙 韩得明 刘勇[2] 

机构地区：[1]新疆医科大学第四临床医学院,新疆 乌鲁木齐 [2]新疆医科大学附属中医医院麻醉科,新疆 乌鲁木齐

出　　处：《临床医学进展》2023年第9期14750-14757,共8页Advances in Clinical Medicine

摘　　要：针刺镇痛效果确切,无成瘾性且相对安全,但其作用机制尚未完全清楚,了解针刺镇痛的机制可以确保其临床应用的疗效。目前认为针刺镇痛的作用机制属于递进式、网络化、多靶点的交互作用,涉及中枢、外周、内分泌、免疫等多个系统及器官。随着针刺镇痛机制的研究不断拓宽,近期神经影像学技术、光遗传学技术及高通量测序技术等多项有潜力的新技术应用于针刺镇痛的评价及其作用机制的探索。现就其相关研究进展作一篇综述如下,分别从针刺镇痛机制研究背景与发展、针刺镇痛外周及中枢作用机制的研究到相关新技术应用的近况进行简要回顾,为针刺镇痛在临床展开更精准的应用提供理论指导。Acupuncture analgesia is effective, non-addictive and relatively safe, but its mechanism of action has not been fully understood. Understanding the mechanism of acupuncture analgesia can ensure the efficacy of its clinical application. Currently, acupuncture analgesia is believed to be a progres-sive, networked, multi-target interaction involving central, peripheral, endocrine, immune systems and other organs. With the continuous expansion of the research on acupuncture analgesia mecha-nism, many potential new technologies, such as neuroimaging technology, optogenetics technology and high-throughput sequencing technology, have been applied to the evaluation of acupuncture analgesia and explore the mechanism of action. Here is a review of its related research progress as follows, from the research background and development of acupuncture analgesia mechanism, pe-ripheral and central mechanism of acupuncture analgesia to the recent status of the application of related new technologies were briefly reviewed, to provide theoretical guidance for more accurate clinical application of acupuncture analgesia.

关 键 词：针刺镇痛 机制研究 神经影像学 光遗传学 高通量测序 

分 类 号：R24[医药卫生—中医临床基础]