野芭蕉对经皮冠状动脉介入术CYP2C19基因中间代谢表型患者的疗效观察  

Observation of the Therapeutic Effect of Wild Plantain on Patients with CYP2C19 Gene In-termediate Metabolic Phenotype during Percutaneous Coronary Intervention

作　　者：潘兴寿[1] 李近都 梁烨[3] 蔡键 班青丽 卢国康 王秋燕 韦唯 李天资[1] 邹才华[5] 

机构地区：[1]右江民族医学院附属医院心血管内科,广西 百色 [2]广西医科大学附属肿瘤医院肝胆外科,广西 南宁 [3]右江民族医学院附属医院教学部,广西 百色 [4]右江民族医学院研究生学院,广西 百色 [5]右江民族医学院附属医院腺体外科,广西 百色

出　　处：《临床医学进展》2023年第9期14935-14943,共9页Advances in Clinical Medicine

摘　　要：目的:探讨野芭蕉对CYP2C19基因中间代谢表型(IMP)患者的疗效及其机制。方法:选90例IMP患者,随机分为中药组和西药组,中药组用常量氯吡格雷 + 石斛野蕉处方治疗,西药组用双倍量氯吡格雷治疗,连用180 ± 10 D。比较两组患者血小板最大聚集率(MPAR)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)、血尿酸(AU)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)、极低密度脂蛋白胆固醇(vLDLC)、甘油三酯(TG)、再梗和出血水平。结果:中药组PMAR有效率高于西药组(P 0.05)。结论:野芭蕉可有效缓解中间代谢型患者血小板紊乱情况,减少经皮冠状动脉介入治疗患者出血和再梗死的发生率,其作用机制与降低患者的血压、血脂、血糖和血尿酸水平有关。Objective: To investigate the therapeutic effect and mechanism of wild plantain on patients with intermediate metabolic phenotype (IMP) of CYP2C19 gene. Methods: 90 patients with IMP were randomly divided into two groups: the Chinese Medicine Group and the Western medicine group. The Chinese medicine group was treated with clopidogrel and wild plantain of Dendrobium, while the western medicine group was treated with clopidogrel of double dosage for 180 ± 10 days. Max-imum platelet aggregation rate (MPAR), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), serum uric acid (AU), total cholesterol (TC), high-density lipo-protein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), low-density lipoprotein cho-lesterol (VLDLC), triglyceride cholesterol (TG), reinfarction and bleeding were compared between the two groups. Results: The effective rate of PMAR in Chinese medicine group was higher than that in Western medicine group (P 0.05). Conclu-sion: Wild plantain can effectively alleviate the platelet disorder in patients with intermediate me-tabolism type and reduce the incidence of bleeding and reinfarction in patients undergoing percu-taneous coronary intervention, the mechanism of action is related to the lowering of blood pressure, blood lipid, blood glucose and blood uric acid.

关 键 词：经皮冠状动脉介入治疗 经皮冠状动脉介入术 CYP2C19基因 血尿酸水平 野芭蕉 再梗死 氯吡格雷 代谢表型 

分 类 号：R54[医药卫生—心血管疾病]