脓毒症致急性肾损伤与微循环障碍的关系研究  

Relationship between Acute Renal Injury In-duced by Sepsis and Microcirculation Disturbance

作　　者：胡洁 罗朋立[1] 

机构地区：[1]青海大学附属医院肾病内科,青海 西宁

出　　处：《临床医学进展》2023年第10期15308-15313,共6页Advances in Clinical Medicine

摘　　要：急性肾损伤发生最常见的原因是脓毒症,脓毒症导致肾脏微循环的改变是脓毒症相关急性肾损伤的主要原因,脓毒症通过炎症反应、球管失衡和血流重分布来影响肾脏微循环,进而导致肾小管坏死,针对病因出现了抗炎、液体复苏和血流重分布的治疗措施。本文旨在研究SA-AKI发生的机制,从而预防脓毒症患者进一步损伤肾脏及减低脓毒症患者死亡率,现就近年研究进展做一综述。Sepsis is the most common cause of acute kidney injury, and the change of renal microcirculation caused by sepsis is the main cause of sepsis-associated acute kidney injury, sepsis affects renal mi-crocirculation through inflammatory reaction, imbalance of bulbar duct and redistribution of blood flow, which leads to tubular necrosis. Anti-inflammatory, fluid resuscitation and redistribution of blood flow have been suggested to treat sepsis. This article aims to study the mechanism of SA-AKI, so as to prevent further renal damage and reduce mortality in patients with sepsis.

关 键 词：急性肾损伤 脓毒症 肾脏微循环 抗炎 液体复苏 

分 类 号：R54[医药卫生—心血管疾病]