子宫自然杀伤细胞及其与妊娠并发症关系的研究进展  

Advances in the Study of Uterine Natural Killer Cells and Their Relationship with Pregnancy Complications

作　　者：杨春燕 

机构地区：[1]黑龙江中医药大学研究生院,黑龙江 哈尔滨

出　　处：《临床医学进展》2023年第10期16543-16550,共8页Advances in Clinical Medicine

摘　　要：子宫自然杀伤细胞(uterine natural killer cells, uNK)作为先天免疫系统的一员,约占妊娠期淋巴细胞总数的70%,在对宿主免受病原体侵袭方面起着重要作用,并参与了一系列影响妊娠成功的生理过程。能通过分泌多种细胞因子,促进滋养层侵袭,重塑螺旋动脉,保护胎儿发育,维持正常妊娠。而失衡的uNK细胞会导致螺旋动脉重构不足和滋养层入侵受损,并与产科并发症如子痫前期、复发性流产、胎儿生长受限密切相关。本篇综述对uNK细胞及其uNK细胞在生理或病理条件下对妊娠的作用进行了介绍,为未来靶向妊娠相关并发症的治疗提供新的线索。Uterine natural killer cells (uNK), as a member of the innate immune system, account for about 70% of the total number of lymphocytes during pregnancy, play an important role in protecting the host from pathogens, and participate in a series of physiological processes that affect the success of pregnancy. It can promote trophoblast invasion, reshape spiral artery, protect fetal development, and maintain normal pregnancy by secreting a variety of cytokines. Unbalanced uNK cells can lead to inadequate spiral artery remodeling and impaired trophoblast invasion, and are closely associ-ated with obstetric complications such as preeclampsia, recurrent abortion, and fetal growth re-striction. This review introduces the role of uNK cells and uNK cells in pregnancy under physiologi-cal or pathological conditions and provides new clues for future therapies targeting pregnan-cy-related complications.

关 键 词：妊娠 子宫自然杀伤细胞 复发性流产 子痫前期 

分 类 号：R71[医药卫生—妇产科学]