维生素D在慢性肾脏病中保护作用的研究进展  

Research Progress on the Protective Effect of Vitamin D in Chronic Kidney Disease

作　　者：周洪 欧云塔娜 张蕾[1] 

机构地区：[1]新疆医科大学第五附属医院肾病科,新疆 乌鲁木齐

出　　处：《临床医学进展》2023年第11期17030-17036,共7页Advances in Clinical Medicine

摘　　要：维生素D是人体产生的一种类固醇激素,与核激素受体维生素D受体(vitamin D receptor, VDR)联合后出现生物学反应。慢性肾脏病(chronic kidney disease, CKD)是一种不可逆的慢性疾病,发病率呈递增趋势。经检测CKD患者大多缺乏维生素D,近年来多项研究均表明维生素D缺乏可以引起钙磷代谢、甲状旁腺功能紊乱,还能促进CKD进展,从而使心脑血管病、骨质疏松、肾性贫血等并发症的风险增加。故本文主要就慢性肾脏病中维生素D保护作用机制的研究进展进行综述。Vitamin D is a steroid hormone produced by the body that reacts biologically in combination with the nuclear hormone receptor vitamin D receptor (VDR). Chronic kidney disease (CKD) is an irre-versible chronic disease with an increasing incidence. It has been detected that most CKD patients lack vitamin D. In recent years, a number of studies have shown that vitamin D deficiency can cause calcium and phosphorus metabolism, parathyroid dysfunction, and promote the progression of CKD, thus increasing the risk of complications such as cardiovascular and cerebrovascular disease, oste-oporosis, and renal anemia. Therefore, this article mainly reviews the research progress of the pro-tective mechanism of vitamin D in chronic kidney disease.

关 键 词：维生素D 慢性肾脏病 保护作用 研究进展 

分 类 号：R69[医药卫生—泌尿科学]