IL-6对住院心力衰竭患者发生心房颤动的预测价值  被引量:1

The Predictive Value of IL-6 in Atrial Fibrillation in Hospitalized Patients with Heart Failure

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作  者:王凤娇 阮士苗 王帅帅[1] 曹丽华 高娟[1] 张文忠[1] 

机构地区:[1]青岛大学附属医院心血管内科,山东 青岛

出  处:《临床医学进展》2023年第11期17293-17300,共8页Advances in Clinical Medicine

摘  要:目的:探讨白介素-6 (IL-6)水平对心力衰竭(HF)患者并发房颤的预测价值。方法:选取2021年9月~2023年8月期间青岛大学附属医院收治的120例心力衰竭患者。根据IL-6的三分位数,将患者分为三组,分析基线特征差异:组1 (0 0.05)。三组之间在血钙水平测定结果方面存在显著差异(2.30 (2.16, 2.36) vs 2.21 (2.15, 2.26) vs 2.19 (2.05, 2.25) mmol/L, P = 0.026)。并发房颤的发生率为31.8%。单因素分析结果显示,年龄、心功能分级、高密度脂蛋白、IL-6和cTnI均为心力衰竭患者并发房颤的主要因素,其中心功能分级和IL-6是其独立危险因素(P 1)。ROC曲线分析显示,IL-6预测心衰患者发生房颤的曲线下面积为0.6672 (95% CI 0.5599 to 0.7745, P < 0.05),灵敏度为0.8293,特异度为0.5263,约登指数为0.3556,最佳截断值为Ln (IL-6) = 1.290。结论:本研究表明,IL-6水平与心力衰竭患者并发房颤密切相关,可作为指标因子用于预测心力衰竭患者发生房颤。Objectives: To assess the predictive value of interleukin-6 (IL-6) levels in heart failure (HF) patients with concomitant atrial fibrillation. Methods: We enrolled 120 HF patients admitted to the Affiliated Hospital of Qingdao University between September 2021 and August 2023. Patients were divided into three groups based on the IL-6 quantile and baseline differences in characteristics were ana-lyzed: Group 1 (0 0.05). Notably, blood calcium levels differed significantly among the three groups (2.30 (2.16, 2.36) vs 2.21 (2.15, 2.26) vs 2.19 (2.05, 2.25) mmol/L, P = 0.026). The incidence of AF was 31.8%. Univariate analysis identified age, cardiac function grade, high-density lipoprotein, IL-6, and cTnI as primary risk factors for AF in HF patients, with cardiac function grade and IL-6 emerging as inde-pendent risk factors (P 1). ROC analysis demonstrated that IL-6 effectively predicted AF in HF patients, yielding an area under the curve of 0.6672 (95% CI 0.5599 to 0.7745, P < 0.05), sen-sitivity of 0.8293, specificity of 0.5263, and a Youden index of 0.3556. The optimal cutoff value was Ln (IL-6) = 1.290. Conclusions: IL-6 levels exhibit a strong association with AF in HF patients and can serve as a valuable predictor for AF occurrence.

关 键 词:心力衰竭 IL-6 心房颤动 

分 类 号:R54[医药卫生—心血管疾病]

 

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