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作 者:任谦谊
机构地区:[1]黑龙江中医药大学第一临床医学院,黑龙江 哈尔滨
出 处:《临床医学进展》2023年第11期17728-17737,共10页Advances in Clinical Medicine
摘 要:目的:探讨明清中医古籍中使用中药内治法治疗鼻鼽的用药特点及组方规律。方法:检索《中华医典》(第五版)中治疗鼻鼽的相关文献。对筛选得到的文献数据采用Excel 2019软件对处方药物的使用频次、四气五味、归经及功效进行统计,采用IBM SPSS Modeler 18.0进行关联规则分析和复杂网络分析,进一步使用Cytoscape_v3.9.1对复杂网络分析结果进行筛选和可视化优化。同时,使用Origin 2021对所包含的药物进行聚类分析。结果:共纳入55首方剂,涉及药物134味,总用药频次452次。出现频次 ≥ 8次的高频中药有14味,前5味药物为甘草、细辛、川芎、白芷、辛夷。用药以温性药、辛味药为主,药物归经主要归肺、胃、脾经。支持度为0.2且最小规则置信度为0.6的中药配伍规则,通过分析得到7个组合。通过聚类分析得到3个聚类处方组合。结论:通过数据挖掘结果显示,明清医家认为鼻鼽,病位在肺,与脾胃关系密切。寒热虚实均可发病,但多为素体有虚外感风寒而发,并可见寒热错杂之证。治疗以散风寒,补其虚兼清里热为主。Objective: To explore the medication characteristics and prescription rules of traditional Chinese medicine internal therapy in the treatment of allergic rhinitis in ancient books of traditional Chi-nese medicine in the Ming and Qing Dynasties. Methods: The relevant literatures on the treatment of allergic rhinitis in the Chinese Medical Code (Fifth Edition) were retrieved. According to the liter-ature data obtained from the screening, Excel 2019 software was used to make statistics on the frequency of use, Four Qi and Five Flavors, meridian tropism and efficacy of prescription drugs. As-sociation rule analysis and complex network analysis were performed using IBM SPSS modeler 18.0. Using Cytoscape In v3.9.1, complex network analysis results are screened and visually optimized. Meanwhile, Origin 2021 was used to cluster the included drugs. Results: A total of 55 prescriptions were included, involving 134 drugs, with a total frequency of 452 times. There are 14 high-frequency traditional Chinese medicines with frequency greater than or equal to 8 times, and the top 5 medicines are liquorice, asarum, Ligusticum chuanxiong, Angelica dahurica and Magnolia. The drugs are mainly warm drugs and pungent drugs, and the drugs are mainly attributed to the lung, stomach and spleen meridians. According to the compatibility rules of traditional Chinese medicine with a support of 0.2 and a minimum rule confidence of 0.6, seven combinations were ob-tained through analysis. Three cluster prescription combinations were obtained by cluster analysis. Conclusion: According to the data mining results, doctors in the Ming and Qing Dynasties believed that allergic rhinitis was located in the lung and closely related to the spleen and stomach. Both cold and heat deficiency and excess can cause the disease, but most of them are caused by deficiency of the body and exogenous wind and cold, and the syndrome of mixed cold and heat can be seen. The treatment is mainly to dispel wind cold, supplement its deficiency and clear away internal heat
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