DFR、抗凝血酶III概况及其在急性肺栓塞中的应用  

DFR, Antithrombin III Profile and Application in Acute Pulmonary Embolism

作　　者：吉米力古·吾吉 韩利梅[1] 刘顺苹 

机构地区：[1]新疆医科大学第二附属医院呼吸内科,新疆 乌鲁木齐

出　　处：《临床医学进展》2023年第12期18751-18756,共6页Advances in Clinical Medicine

摘　　要：急性肺栓塞是多种因素共同作用下发生的、可严重危及生命的一种疾病。因其临床表现、体征缺乏特异性,单一检测往往不足以满足诊断需要,误诊率及漏诊率大,病死率高。故在疾病初期采取何种有效的方式进行诊断已成为临床研究热题。D-二聚体为反映纤溶亢进的指标,纤维蛋白原为凝血的指标,DFR作为D-D与Fbg的比值,在一定程度上可以反映纤溶与凝血之间的平衡。抗凝血酶III具有显著的抗凝血作用,其水平下降影响机体抗凝作用,促进血栓形成。Acute pulmonary embolism is one of the most common acute and critical diseases occurring under the combined effect of many factors. Due to the lack of specificity of its clinical manifestations, the degree of severity varies, the misdiagnosis rate and missed diagnosis rate are large, and the death rate is high. Therefore, what kind of effective way to diagnose at the early stage of the disease has become a hot topic of clinical research. D-dimer is an indicator of hyperfibrinolysis, fibrinogen is an indicator of coagulation, and DFR, as the ratio of D-D to Fbg, can reflect the balance between fibri-nolysis and coagulation to a certain extent. Antithrombin III has a significant anticoagulant effect, and a decrease in its level affects the body’s anticoagulant effect and promotes thrombosis.

关 键 词：急性肺栓塞 DFR 抗凝血酶III 

分 类 号：R56[医药卫生—呼吸系统]