冠心病合并OSAHS患者CACS与AHI、LaSO₂的相关性分析  

Correlation Analysis of CACS and AHI, LaSO2 in Patients with Coronary Heart Disease and OSAHS

作　　者：李娇[1,2] 孙建秀 高娟 曹丽华[1] 张文忠 

机构地区：[1]青岛大学附属医院心内科,山东 青岛 [2]招远市中医医院,山东 烟台

出　　处：《临床医学进展》2024年第1期1323-1330,共8页Advances in Clinical Medicine

摘　　要：目的:探讨冠心病合并OSAHS患者的CACS与AHI、LaSO2之间的相关性。方法:回顾性收集2022年04月~2023年02月在青岛大学附属医院行PSG + CCTA的病例共114例。根据CCTA测得的CACS积分的情况,将患者分为无心血管病风险组:CACS = 0分(n = 49例),有心血管病风险组:CACS > 0分(n = 65例)。比较两组间相关指标的差异性,并明确CACS与AHI、LaSO2之间的相关及回归关系。结果:与无心血管风险组相比,有心血管风险组年龄、AHI更高,LaSO2更低,差异有统计学意义(p s = −0.378, p 2是CACS的主要危险因素(B值分别为7.352,−5.936,β值分别为0.283、−0.133,p值分别为0.002、0.038)。在控制协变量后,AHI、LaSO2对CACS的效应仍显著(B值分别为9.653,−7.674,β值分别为0.371、−0.172,p值分别为0.014、0.045),可作为CSCS的独立预测因子。结论:阻塞性睡眠呼吸暂停严重程度与CACS严重程度呈正相关,且AHI与CACS呈正相关,LaSO2与CACS呈负相关,AHI、LaSO2可被视为冠状动脉疾病高风险的独立预测因子(基于CACS)。Purpose: To investigate the correlation between CACS and AHI, LaSO2 in patients with CHD com-bined with OSAHS. Methods: This study was a retrospective case analysis. 114 patients who under-went PSG + CCTA in the Affiliated Hospital of Qingdao University from April 2022 to April 2023 were collected. According to the CACS measured by CCTA, the patients were divided into two groups: the group without cardiovascular risk: CACS = 0 (n = 49 cases), and the group with cardiovascular risk: CACS > 0 (n = 65 cases). The differences of relevant indexes in different groups were compared. And the correlation and regression relationship between CACS and AHI, LaSO2 were clarified. Results: Compared with the group without cardiovascular risk, the group with cardiovascular risk had high-er age, AHI and lower LaSO2, and the difference was statistically significant (p 2 (rs = −0.378, p 2 were the main risk factors of CACS (B = 7.352, −5.936, β = 0.283, −0.133, p = 0.002, 0.038). After controlling for covariables, AHI and LaSO2 still had significant effects on CACS (B = 9.653, −7.674, β = 0.371, −0.172, p = 0.014, 0.045), and were independent risk factors for CACS. Conclusions: The severity of OSAHS was positively correlated with the severity of CACS. AHI was positively correlated with CACS and LaSO2 was negatively correlated with CACS, which could be considered as independent predic-tors of high risk of coronary artery disease (based on CACS).

关 键 词：阻塞性睡眠呼吸暂停 低通气综合征 冠心病 冠脉钙化积分 

分 类 号：R54[医药卫生—心血管疾病]