新生儿脑损伤发生机制及其产前相关高危因素研究进展  

Research Progress on the Pathogenesis of Neonatal Brain Injury and Its Related Risk Factors before Birth

作　　者：邢丽媛 李亚军 刘红艳 邢怡 郭甜甜 张楚楚 

机构地区：[1]西安医学院第一附属医院,陕西 西安 [2]西北妇幼儿童医院,陕西 西安 [3]西安医学院,陕西 西安

出　　处：《临床医学进展》2024年第1期2173-2180,共8页Advances in Clinical Medicine

摘　　要：新生儿缺氧缺血性脑病(Hypoxic ischemic encephalopathy, HIE)是由于新生儿期严重缺氧脑损伤引起的复杂生理、细胞和分子变化。导致过早死亡或各种终身发病率,包括癫痫发作、意识改变、呼吸无力、肌肉紧张度差或代谢紊乱等急性症状,以及脑瘫、癫痫、智力残疾和行为障碍等慢性疾病。本文分析了新生儿缺氧缺血性脑病(HIE)可能的发病机制及如分娩孕周、出生体重、孕母合并症、胎盘因素等相关危险因素对新生儿缺氧缺血性脑病的影响,目的是讨论相关危险因素对HIE发生的影响,为预防HIE的发生提供指导意义。Neonatal hypoxic ischemic encephalopathy is a complex physiological, cellular and molecular change caused by severe hypoxic brain injury in the neonatal period. Causes premature death or a variety of lifetime morbidity, including acute symptoms such as seizures, altered consciousness, respiratory weakness, poor muscle tone or metabolic disorders, as well as chronic conditions such as cerebral palsy, epilepsy, intellectual disability and behavioural disorders. This paper analyzed the possible pathogenesis of neonatal hypoxic ischemic encephalopathy and the influence of related risk factors such as gestational week, birth weight, maternal comorbiditions, placental factors and other risk factors on neonatal hypoxic ischemic encephalopathy, with the purpose of discussing the influence of related risk factors on the occurrence of HIE and providing guidance for the prevention of HIE.

关 键 词：新生儿缺氧缺血性脑病 新生儿脑损伤发生机制 产前相关高危因素 

分 类 号：R72[医药卫生—儿科]