检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
机构地区:[1]华中科技大学同济医学院附属协和医院肾内科,湖北 武汉
出 处:《临床医学进展》2024年第2期4352-4358,共7页Advances in Clinical Medicine
摘 要:膜性肾病(membranous nephropathy, MN)是具有共同的组织病理学模式的一种异质性疾病,常表现为肾病综合征(nephrotic syndrome, NS),是成人NS最常见的原因。MN的病因多样,其发病机制尚未完全阐明,但多认为与足细胞损伤有关,靶抗原的发现为其发病机制、诊断和治疗提供了新的方向。本文总结了MN的病因、分类、靶抗原,讨论其发病机制、病理特征等,以期为MN的早期诊断及治疗提供新的见解。Membranous nephropathy (MN) manifests as a heterogeneous disease sharing a common histo-pathological pattern, frequently presenting as Nephrotic syndrome (NS), and stands as the pre-dominant cause of NS among adults. The etiology of MN exhibits considerable diversity, and its pathogenesis remains incompletely elucidated, albeit the prevailing belief in its association with podocyte injury. Notably, the identification of target antigens has introduced novel dimensions to the understanding of MN’s pathogenesis, diagnosis, and therapeutic strategies. This article endeav-ors to comprehensively delineate the etiological spectrum, classification intricacies, and pertinent target antigens characterizing MN. Furthermore, it delves into the nuanced exploration of its path-ogenesis and pathological attributes, thereby aiming to furnish novel perspectives conducive to the advancement of early diagnostic modalities and therapeutic interventions for MN.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.222