基于“阴成形”理论探讨骨松汤辅助治疗老年骨质疏松症的临床疗效观察  

Clinical Observation of Gu Song Decoction (GSD) for Senile Osteoporosis Patients Based on the Theory of “Yin Forming”

作　　者：朱婵 江雯[1,2] 杨姣 张强 邱现良[1] 陈秋 

机构地区：[1]四川大学华西第二医院中医科,四川 成都 [2]出生缺陷与相关妇儿疾病教育部重点实验室,四川 成都 [3]四川省骨科医院足踝科,四川 成都 [4]成都中医药大学附属医院内分泌科,四川 成都

出　　处：《临床医学进展》2024年第2期4498-4505,共8页Advances in Clinical Medicine

摘　　要：目的:观察骨松汤对老年性骨质疏松症的临床治疗效果。方法:收集成都中医药大学附属医院骨质疏松专科门诊及内分泌科住院的老年性骨质疏松患者64例,其中观察组33例、对照组31例。两组均采用标准抗骨质疏松药物,观察组加用骨松汤剂。记录两组治疗前腰髋部VAS评分(疼痛可视化量表)、其他主要症状评分、骨密度值(腰1~4椎体,股骨颈);治疗3月后腰髋部VAS评分、其他主要症状评分;治疗12个月后腰髋部VAS评分、骨密度值并统计12个月内骨折再发率及不良反应发生率。结果:治疗后,观察组VAS评分改善更明显,差异有统计学意义(P < 0.05)。观察组“腰膝酸软”、“下肢疼痛”有明显改善,与对照组相比,差异有统计学意义(P < 0.05)。治疗12个月后,两组患者L1~4椎体骨密度均有增加;两组股骨颈骨密度均无明显变化,两组间对比无统计学差异。结论:骨松汤辅助治疗老年骨质疏松症用药安全,能减轻患者疼痛;改善骨质疏松主要症状;联合西药抗骨质疏松药物可提高1年后腰椎骨密度。Objective: The purpose of this study was to observe the effects of GSD for senile patients with osteo-porosis. Method: 64 senile patients with osteoporosis from Hospital of Chengdu University of TCM were randomly divided into observation group (group A: 33 cases) and control group (group B: 31 cases). Standard medications were used in all those patients. Additionally, GSD were used in group A. Baseline Visual Analogue Scale (VAS), symptom scores (SS), and Bone Mineral Density (BMD) (lumbar 1~4 vertebra and femoral neck) were recorded. With 3 months treatment, VAS and SS were repeatedly measured;VAS and BMD were recorded again after 12 months. During this period, all the fracture recurrence events and adverse effect events were reported. Results: We observed that compared to group B, there was a significant VAS promotion in group A (P < 0.05);further-more, SS including “weakness of low back and knee”, “Low limb pain” got a remarkable relief (P < 0.05). Notably, both of the group show a BMD enhance in L1~4 vertebrae, while no significant change in femoral neck. Conclusion: Finally, the combination treatment with GSD was safe and well tolerated. It could have synergistic activity that benefits patients with hefty pain. Combination of anti-osteoporosis drugs can increase lumbar bone density after 1 year.

关 键 词：中医药 骨质疏松症 唑来膦酸钠 临床研究 

分 类 号：R58[医药卫生—内分泌]