SOCS3、IL6、PTGS2、FOS在腹主动脉瘤发生发展中的生物信息学研究  

SOCS3, IL6, PTGS2, and FOS in the Occurrence as Well as Continuation of Aneurysms of the Abdominal Aorta: A Bioinformatics Investigation

作　　者：王琨[1] 辛海[1] 官笑梅 邱德强 李君[1] 

机构地区：[1]青岛大学附属医院血管外科,山东 青岛

出　　处：《临床医学进展》2024年第2期4743-4753,共11页Advances in Clinical Medicine

摘　　要：腹主动脉瘤(Abdominal aortic aneurysm, AAA)是一种主动脉疾病,通常无症状,但可导致主动脉进行性扩张和突然破裂。因此,死亡率很高。腹主动脉瘤受到许多与遗传和环境有关的因素影响,炎症和免疫系统的反应会导致这种疾病的发生和发展。除了手术干预,目前还没有专门有效的药物来治疗腹主动脉瘤的进展和破裂。可以通过对基因组和转录组数据的大规模评估来确定潜在的生物标志物和治疗靶点,以便更好地了解这种疾病的复杂分子途径和机制,并促进开发管理腹主动脉瘤的个性化医疗策略。Abdominal aortic aneurysm (AAA) is an aortic disease, which is typically asymptomatic but can lead to progressive dilation and abrupt rupture of the aorta. Consequently, the mortality rate is high. AAA is impacted by many factors related to genetics and environment, and inflammation and re-sponse of the immune system assist in the growth and progression of this disease. Aside from sur-gical intervention, there are currently no specific and effective medication remedies for preventing the progression and rupture of AAA. Potential biomarkers and therapeutic targets can be identified through a large-scale assessment of genomic and transcriptomic data in order to better understand the complex molecular pathways and mechanisms of this disease and to facilitate the development of personalized medical strategies for managing AAA.

关 键 词：生物信息学分析 腹主动脉瘤 关键基因 信号通路 诊断生物标志物 蛋白质–蛋白质相互作用 

分 类 号：R54[医药卫生—心血管疾病]